Eubacterial tmRNA sequences and uses thereof
View Patent ↗The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use of the sequences for the development of diagnostic assays.
1. An isolated nucleic acid sequence selected from the group consisting of the tmDNA sequence for Staphylococcus epidermidis set forth in SEQ ID NO: 31, the complement of said tmDNA sequence, and the tmRNA sequence set forth in SEQ ID NO: 85.
2. A method for diagnosing the presence of Staphylococcus epidermidis comprising determining the presence of a bacterial nucleic acid sequence selected from the group consisting of the tmDNA sequence for Staphylococcus epidermidis set forth in SEQ ID NO: 31, the complement of said tmDNA sequence, and the tmRNA sequence set forth in SEQ ID NO: 85.
3. The method of claim 2 wherein the determination is made by performing an amplification-based assay.
4. The isolated nucleic acid sequence of claim 1 , wherein the nucleic acid sequence is the tmDNA sequence for Staphylococcus epidermidis set forth in SEQ ID NO: 31.
5. The method of claim 2 , wherein the bacterial nucleic acid sequence is the tmDNA sequence for Staphylococcus epidermidis set forth in SEQ ID NO: 31.
6. The method of claim 3 , wherein the bacterial nucleic acid sequence is the tmDNA sequence for Staphylococcus epidermidis set forth in SEQ ID NO: 31.