IP Library › Granted Patent US 7,014,854
Granted Patent B2
US 7,014,854 · App. 10/334,701 · Granted Mar 21, 2006

Method for retarding or precluding Alzheimer's dementia

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Quick Facts
Patent No.
US 7,014,854
App. No.
10/334,701
Granted
Mar 21, 2006
Kind
B2
Abstract

A method for treating a condition related to the development of Alzheimer's disease (AD) is disclosed. The method involves the removal of circulating autoantibodies of a biochemical marker or markers, specifically human glial fibrillary acidic protein (GFAP) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from the sera of a patient in an amount effective to reduce or eliminate phagocytosis of astrocytic cells. The invention further includes a process of immune system modulation effective for autoantibody removal.

Claims (3)

1. A process for retarding phagocytosis of astrocytic cells comprising:

determining the presence in body fluid of autoantibodies against glial fibrillary acidic protein (GFAP); and

removing said autoantibodies from said body fluid whereby said removing retards phagocytosis of astrocytic cells.

Assignments (8)
GRANT OF SECURITY INTEREST Recorded Jul 25, 2008
From: NANOGEN, INC.
To: PORTSIDE GROWTH & OPPORTUNITY FUND, AS COLLATERAL AGENT
Reel/Frame 021291/0605 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2008
From: NANOGEN POINT OF CARE, INC.
To: NANOGEN, INC.
Reel/Frame 020826/0087 →
ASSIGNMENT OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Apr 15, 2008
From: THE CANADA TRUST COMPANY
To: NANOGEN, INC.
Reel/Frame 020807/0247 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 25, 2006
From: NANOGEN POINT OF CARE INC.
To: NANOGEN INC.
Reel/Frame 017696/0861 →
CHANGE OF NAME Recorded May 19, 2006
From: SYN X PHARMA INC.
To: NANOGEN POINT OF CARE INC.
Reel/Frame 017656/0382 →
SECURITY INTEREST Recorded Feb 12, 2004
From: SYNX PHARMA INC.
To: NANOGEN, INC.
Reel/Frame 014337/0010 →
SECURITY AGREEMENT Recorded Jul 18, 2003
From: SYNX PHARMA INC.
To: CANADA TRUST COMPANY, THE
Reel/Frame 014242/0790 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 14, 2003
From: JACKOWSKI, GEORGE; FURESZ, SHIRLEY
To: SYN X PHARMA
Reel/Frame 013953/0360 →