Antibacterial wound dressing
View Patent ↗An antibacterial wound dressing is based on, or derived from, gel-forming fibres such as carboxymethyl cellulose or alginate fibres having silver ions linked thereto at some but not all of the exchangeable sites such that the distribution of silver ions over the exchangeable sites is substantially uniform. The silvered fibres for the wound dressing can be prepared by contacting an assembly of precursor gel-forming fibres having exchangeable sites under conditions which do not cause irreversible gelling of the fibres with an amount of a solution containing silver ions so as to link silver ions at some but not all of the exchangeable sites, the whole of the assembly of precursor gel-forming fibres being contacted essentially simultaneously with the entire solution containing silver ions.
1. A process for producing silvered fibres for use in antibacterial wound dressings including the steps of
(i) forming an assembly of precursor gel-forming fibres having thereon exchangeable sites capable of exchange with silver ions to link silver ions to the fibre,
(ii) forming a solution containing silver ions comprising a soluble silver salt and an aqueous organic solvent, and
(iii) essentially simultaneously contacting the assembly of precursor gel-forming fibres with the solution containing silver ions under conditions which do not cause irreversible gelling of the fibres, thereby to link silver ions at exchangeable sites, in which process the whole of the assembly of precursor gel-forming fibres is contacted essentially simultaneously with the entire solution containing silver ions, rather than being contacted gradually or partially, the solution containing silver ions being used in an amount such that enough silver ions are present to link with not more than about 20% of the exchangeable sites on the precursor gel-forming fibres, wherein the distribution of silver ions over the exchangeable sites is essentially uniform as shown by the essentially uniform coloration of the dressing.
2. A process according to claim 1 , in which the process is a batch process wherein the assembly of precursor gel-forming fibres is contacted with the solution containing silver ions by dipping it rapidly and entirely into the solution.
3. A process according to claim 2 , wherein the solution is held in a container and is an amount required completely to cover the precursor gel-forming fibres so that the fibres fill the solution within the container.
4. A process according to claim 2 , wherein the time interval between the beginning of the dipping of the assembly of precursor gel-forming fibres to form the wound dressing into the solution and the moment at which the assembly of precursor gel-forming fibres to form the wound dressing is entirely dipped into the solution is not more than about 10 seconds.
5. A process according to claim 4 , wherein said time interval is not more than 5 seconds.
6. A process according to claim 2 , wherein the assembly of precursor gel-forming fibres to be dipped is dry.
7. A process according to claim 3 , wherein the solution containing silver ions is held in a closed container.
8. A process according to claim 3 , wherein the solution containing silver ions is held in an open container.
9. A process according to claim 1 , wherein the precursor gel-forming fibres are in tow form or staple fibre form.
10. A process according to claim 1 , wherein the assembly of precursor gel-forming fibres is in the form of a hank.
11. A process according to claim 1 , wherein eh precursor gel-forming fibres are carboxymethyl cellulose fibres.
12. A process according to claim 11 , wherein the carboxymethyl cellulose fibre is carboxymethylated lyocell.
13. A process according to claim 12 , wherein the carboxymethylated lyocell has a degree of substitution of 0.2 to 0.4.
14. A process according to claim 1 , wherein the precursor gel-forming fibres are calcium alginate or sodium-calcium alginate fibres.
15. A process according to claim 1 , wherein the assembly of silvered, gel-forming fibres is processed to form wound dressings.
16. A process according to claim 1 , wherein the solution containing silver ions is used in an amount such that enough silver ions are present to link with not more than about 10% of the exchangeable sites on the precursor gel-forming fibres.