Therapeutic agent for nerve damage
View Patent ↗The present invention provides a therapeutic agent for nerve damages such as those caused by spinal cord injury or nerve trauma, which includes, as an active ingredient, a low-molecular-weight saccharide composed of at least glucuronic acid and/or N-acetylglucosamine or a pharmaceutically acceptable salt thereof. The present invention also provides a therapeutic agent for nerve damages which includes, as an active ingredient, preferably a low-molecular-weight hyaluronic acid, more preferably hyaluronic acid disaccharide to hyaluronic acid 2,500-saccharide, further more preferably hyaluronic acid disaccharide to hyaluronic acid 50-saccharide, much more preferably hyaluronic acid tetrasaccharide, or a pharmaceutically acceptable salt thereof.
1. A method of treating nerve damage, comprising administering an effective amount of a hyaluronic acid oligosaccharide or a pharmaceutically acceptable salt thereof to an animal suffering from nerve damage, wherein the hyaluronic acid oligosaccharide is selected from hyaluronic acid disaccharide to hyaluronic acid 50-saccharide.
2. The method according to claim 1 , wherein nerve damage is caused by spinal cord injury or nerve trauma.
3. A method of recovering a nervous function lost due to a spinal cord injury comprising administering an effective amount of a hyaluronic acid oligosaccharide or a pharmaceutically acceptable salt thereof to an animal suffering from loss of nervous function, wherein the hyaluronic acid oligosaccharide is selected from hyaluronic acid disaccharide to hyaluronic acid 50-saccharide.
4. The method according to claim 1 , wherein the nerve damage is selected from the group consisting of a decrease of a nervous function, demyelination, an edema in white matter, a reduction in axon number and tissue damage caused by a spinal cord injury or nerve trauma.
5. The method according to claim 1 , wherein the hyaluronic acid oligosaccharide is hyaluronic acid tetrasaccharide.
6. The method according to claim 2 , wherein the hyaluronic acid oligosaccharide is hyaluronic acid tetrasaccharide.
7. The method according to claim 3 , wherein the hyaluronic acid oligosaccharide is hyaluronic acid tetrasaccharide.
8. The method according to claim 4 , wherein the hyaluronic acid oligosaccharide is hyaluronic acid tetrasaccharide.