Methods and compositions for treating ocular disease
View Patent ↗The use of collectins and/or surfactant proteins for the treatment and prevention of ocular disease.
1. A method for treating an ocular disease caused by a bacterial microbe in a subject, the method comprising administering into the eye of a subject, a pharmaceutical composition comprising a therapeutically effective amount of a surfactant protein-A or surfactant protein-D.
2. The method of claim 1 , wherein said ocular disease is bacterial keratitis.
3. The method of claim 1 , wherein said subject is a contact-lens wearer.
4. The method of claim 1 , wherein said surfactant protein is applied topically.
5. The method of claim 1 , further comprising administering a second therapeutic agent to said subject.
6. The method of claim 1 wherein said surfactant protein is surfactant protein-D.
7. The method of claim 1 , wherein said microbe is a gram-negative bacterium.
8. The method of claim 7 , wherein said gram-negative bacterium is Pseudomonas aeruginosa.
9. A method for treating an ocular disease caused by a bacterial microbe in a subject, the method comprising administering into the eye of a subject, a pharmaceutical composition comprising a therapeutically effective amount of a surfactant protein.
10. A method for reducing bacterial invasion of corneal cells, the method comprising administering into the eye of a subject, a pharmaceutical composition comprising a therapeutically effective amount of surfactant protein-D.