Topical skin barriers and methods of evaluation thereof
View Patent ↗A topical skin barrier for protecting and promoting healing of skin, and for providing comfort to a patient, comprises a semi-solid hydrocarbon and a water-absorbing compound. The topical skin barrier effectively adheres to skin, affords protection from moisture and waste, and provides transparency in use. Methods of in vitro evaluation are for (i) a composition's protection from moisture and waste, and (ii) a composition's adhesion to skin.
1. A topical skin barrier for protecting and promoting healing of skin, the topical skin barrier comprising:
in a range by weight from about 25.0% to about 95.0%, a semi-solid hydrocarbon; and
in a range by weight from about 5.0% to about 75.0% a cellulose gum having a degree of substitution between 0.80-0.95;
wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.5 inches per 2 hours.
2. The topical skin barrier of claim 1 , further comprising, in a range by weight from about 0.1% to about 20.0% dimethicone.
3. The topical skin barrier of claim 1 , further comprising, in a range by weight from about 0.1% to about 5.0% tocopheryl acetate.
4. The topical skin barrier of claim 1 , wherein said semi-solid hydrocarbon is selected from the group consisting of petrolatum and white petrolatum.
5. A topical skin barrier comprising:
in a range by weight from about 25.0% to about 90.0%, a semi-solid hydrocarbon;
in a range by weight from about 5.0% to about 50.0% a cellulose gum having a degree of substitution between 0.80-0.95; and
in a range by weight from about 0.5% to about 2.5%, an antifungal agent,
wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.5 inches per 2 hours.
6. The topical skin barrier of claim 5 , further comprising, in a range by weight from about 0.1% to about 20.0% dimethicone.
7. The topical skin barrier of claim 5 , further comprising, in a range by weight from about 0.1% to about 5.0% tocopheryl acetate.
8. The topical skin barrier of claim 5 , wherein said semi-solid hydrocarbon is selected from the group consisting of petrolatum and white petrolatum.
9. The topical skin barrier of claim 5 , wherein said antifungal agent is selected from the group consisting of miconazole nitrate and clotrimazole.
10. A topical skin barrier comprising:
in a range by weight from about 25.0% to about 90.0%, a semi-solid hydrocarbon;
in a range by weight from about 5.0% to about 50.0% a cellulose gum having a degree of substitution between 0.80-0.95; and
in a range by weight from about 0.1% to about 10.0%, an odor control agent,
wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.5 inches per 2 hours.
11. The topical skin barrier of claim 10 , further comprising, in a range by weight from about 0.1% to about 20.0% dimethicone.
12. The topical skin barrier of claim 10 , further comprising, in a range by weight from about 0.1% to about 5.0% tocopheryl acetate.
13. The topical skin barrier of claim 10 , wherein said semi-solid hydrocarbon is selected from the group consisting of petrolatum and white petrolatum.
14. The topical skin barrier of claim 1 , wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.25 inches per 2 hours.
15. The topical skin barrier of claim 5 , wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.25 inches per 2 hours.
16. The topical skin barrier of claim 10 , wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.25 inches per 2 hours.
17. The topical skin barrier of claim 1 , wherein the cellulose gum is carboxymethylcellulose.
18. The topical skin barrier of claim 2 , wherein the cellulose gum is carboxymethylcellulose.
19. The topical skin barrier of claim 3 , wherein the cellulose gum is carboxymethylcellulose.
20. The topical skin barrier of claim 4 , wherein the cellulose gum is carboxymethylcellulose.
21. The topical skin barrier of claim 5 , wherein the cellulose gum is carboxymethylcellulose.
22. The topical skin barrier of claim 6 , wherein the cellulose gum is carboxymethylcellulose.
23. The topical skin barrier of claim 7 , wherein the cellulose gum is carboxymethylcellulose.
24. The topical skin barrier of claim 8 , wherein the cellulose gum is carboxymethylcellulose.
25. The topical skin barrier of claim 9 , wherein the cellulose gum is carboxymethylcellulose.
26. The topical skin barrier of claim 10 , wherein the cellulose gum is carboxymethylcellulose.
27. The topical skin barrier of claim 11 , wherein the cellulose gum is carboxymethylcellulose.
28. The topical skin barrier of claim 12 , wherein the cellulose gum is carboxymethylcellulose.
29. The topical skin barrier of claim 13 , wherein the cellulose gum is carboxymethylcellulose.
30. The topical skin barrier of claim 14 , wherein the cellulose gum is carboxymethylcellulose.
31. The topical skin barrier of claim 15 , wherein the cellulose gum is carboxymethylcellulose.
32. The topical skin barrier of claim 16 , wherein the cellulose gum is carboxymethylcellulose.
33. A topical skin barrier for protecting and promoting healing of skin, the topical skin barrier comprising:
in a range by weight from about 25.0% to about 95.0%, a semi-solid hydrocarbon; and
in a range by weight from about 5.0% to about 75.0% a cellulose gum having a degree of substitution between 0.80-0.95;
wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.5 inches per 2 hours; and
wherein said topical skin barrier is substantially transparent to permit visual observation of skin under said topical skin barrier.
34. A topical skin barrier comprising:
in a range by weight from about 25.0% to about 90.0%, a semi-solid hydrocarbon;
in a range by weight from about 5.0% to about 50.0% a cellulose gum having a degree of substitution between 0.80-0.95;
in a range by weight from about 0.5% to about 2.5%, an antifungal agent,
wherein said topical skin barrier limits moisture penetration through said topical skin barrier to a moisture penetration of less than 0.5 inches per 2 hours; and
wherein said topical skin barrier is substantially transparent to permit visual observation of skin under said topical skin barrier.
35. A topical skin barrier for protecting and promoting healing of skin, the topical skin barrier comprising:
in a range by weight from about 25.0% to about 95.0%, a semi-solid hydrocarbon; and
in a range by weight from about 5.0% to about 75.0% a cellulose gum having a degree of substitution between 0.80-0.95;
wherein said topical skin barrier is substantially transparent to permit visual observation of skin under said topical skin barrier.
36. A topical skin barrier comprising:
in a range by weight from about 25.0% to about 90.0%, a semi-solid hydrocarbon;
in a range by weight from about 5.0% to about 50.0% a cellulose gum having a degree of substitution between 0.80-0.95; and
in a range by weight from about 0.5% to about 2.5%, an antifungal agent;
wherein said topical skin barrier is substantially transparent to permit visual observation of skin under said topical skin barrier.