Bottle and cap assembly
View Patent ↗A fluid container and method for inhibiting the growth of microbes in liquid nutrient in a container, the container having an interior surface having a metal-ion sequestering agent for removing a designated metal ion from the liquid nutrient for inhibiting growth of microbes in the liquid nutrient.
1. A bottle and cap assembly for containing a liquid nutrient having a pH equal to or greater than about 2.5, said bottle having an interior surface having a polymeric layer thereon, said polymeric layer having a metal-ion sequestering agent for removing a designated metal ion from said liquid nutrient for inhibiting growth of microbes in said liquid nutrient, said metal-ion sequestering agent comprises derivatized nanoparticles comprising inorganic nanoparticles having an attached metal-ion sequestrant, wherein said inorganic nanoparticles have an average particle size of less than 200 nm and the derivatized nanoparticles have a stability constant greater than 10 10 with iron (III), said metal-ion sequestering agent is immobilized in said polymeric layer and comprises 0.1 to 50.0% by weight of the polymeric layer, and the polymeric layer contacts the liquid contained therein and is permeable to water.
2. A bottle and cap assembly according to claim 1 wherein said metal-ion sequestering agent is immobilized on the surface of said bottle and has a stability constant greater than 10 10 with iron (III).
3. A bottle and cap assembly according to claim 1 wherein said sequestering agent is immobilized on the surface of said bottle and has a high-affinity for biologically important metal ions.
4. A bottle and cap assembly according to claim 1 wherein said sequestering agent is immobilized on the surface of said bottle and has a high-selectivity for biologically important metal ions.
5. A bottle and cap assembly according to claim 1 wherein said sequestering agent has a high-selectively for certain metal ions but a low-affinity for at least one other ions.
6. A bottle and cap assembly according to claim 1 wherein said certain metal ions comprises Mn, Zn, Cu and Fe and said other at least one ion comprises calcium.
7. A bottle and cap assembly according to claim 1 wherein said metal-ion sequestering agent is immobilized on the surface of said bottle and has a stability constant greater than 10 20 with iron (III).
8. A bottle and cap assembly according to claim 1 wherein said metal-ion sequestering agent is immobilized on the surface of said bottle and has a stability constant greater than 10 30 with iron (III).
9. A bottle and cap assembly according to claim 1 wherein said inorganic nanoparticles have an average particle size of less than 100 nm.
10. A bottle and cap assembly according to claim 1 wherein said metal-ion sequestrant comprises an alpha amino carboxylate, a hydroxamate, or a catechol functional group.
11. A bottle and cap assembly according to claim 1 wherein said metal-ion sequestrant is attached to to inorganic nanoparticle by reacting the inorganic nanoparticle with a silicon alkoxide intermediate of the sequestrant having the general formula:
Si(OR) 4−x R′ x ;
wherein x is an integer from from 1 to 3
R is an alkyl group; and
R′ is an organo group containing an alpha amino carboxylate, a hydroxamate, or a catechol.
12. A bottle and cap assembly according to claim 1 wherein said bottle is made of a plastic material.
13. A bottle and cap assembly according to claim 1 wherein said liquid nutrient comprises a beverage.
14. A bottle and cap assembly according to claim 1 wherein said bottle is made of a material that includes said sequestering agent.
15. A bottle and cap assembly for containing a liquid nutrient having a pH equal to or freater than about 2.5 said cap having an interior surface having a polymeric layer thereon, said polymeric layer having a metal-ion sequestering agent for removing a designated metal ion from said liquid nutrient for inhibiting growth of microbes in said liquid nutrient, said metal-ion sequestering agent comprises derivatized nanoparticles comprising inorganic nanoparticles having an attached metal-ion sequestrant, wherein said inorganic nanoparticles have an average particle size of less than 200 nm and the derivatized nanoparticles have a stability constant greater than 10 10 with iron (III), said metal-ion sequestering agent is immobilized in said polymeric layer and comprises 0.1 to 50.0% by weight of the polymeric layer, and the polymeric layer is capable of contacting the liquid contained therein and is permeable to water.