Compositions for reducing the incidence of drug induced arrhythmia
View Patent ↗In accordance with the present invention, novel methods and formulations are provided for treating and preventing the incidence of drug-induced pro-arrhythmia, including torsades de pointes. The methods and formulations comprise a combination of a drug that induces torsade de pointes, such as Class III antiarrhythmics, certain antimicrobials, antihistamines, antidepressants, antipsychotics, diuretics, with an aspirin and/or a statin. In certain embodiments, the compositions and methods for treatment comprise azimilide and aspirin and/or a statin. These compositions may be administered by different routes, including orally. In certain embodiments where the antiarrhythmic is azimilide it may be administered orally in a dose of about 25 mg to about 300 mg.
1. A method for reducing the incidence of azimilide-induced torsades de pointes consisting essentially of administering azimilide and aspirin to a patient having cardiac arrhythmia.
2. The method of claim 1 , wherein the azimilide is administered daily in amounts from about 75 mg to about 300 mg.
3. The method of claim 1 , wherein the aspirin is administered daily in amounts from about 80 mg to about 200 mg.
4. The method of claim 2 , wherein the azimilide is administered daily in an amount of about 75 mg.
5. The method of claim 2 , wherein the azimilide is administered daily in an amount of about 100 mg.
6. The method of claim 2 , wherein the azimilide is administered daily in an amount of about 125 mg.
7. A method for reducing the incidence of azimilide-induced torsades de pointes consisting essentially of administering azimilide and a statin to a patient having cardiac arrhythmia.
8. The method of claim 7 , wherein the azimilide is administered daily in amounts from about 75 mg to about 300 mg.
9. The method of claim 8 , wherein the azimilide is administered daily in an amount of about 75 mg.
10. The method of claim 8 , wherein the azimilide is administered daily in an amount of about 100 mg.
11. The method of claim 8 , wherein the azimilide is administered daily in an amount of about 125 mg.
12. A method for reducing the incidence of azimilide-induced torsades de pointes consisting essentially of administering azimilide, aspirin, and a statin to a patient having cardiac arrhythmia.
13. The method of claim 12 , wherein the azimilide is administered daily in amounts from about 75 mg to about 300 mg.
14. The method of claim 13 , wherein the azimilide is administered daily in an amount of about 75 mg.
15. The method of claim 13 , wherein the azimilide is administered daily in an amount of about 100 mg.
16. The method of claim 13 , wherein the azimilide is administered daily in an amount of about 125 mg.
17. The method of claim 12 , wherein the aspirin is administered daily in amounts from about 80 mg to about 200 mg.
18. The method of claim 1 , wherein the cardiac arrhythmia is atrial fibrillation.
19. The method of claim 7 , wherein the cardiac arrhythmia is atrial fibrillation.
20. The method of claim 12 , wherein the cardiac arrhythmia is atrial fibrillation.
21. The method of claim 1 , wherein the cardiac arrhythmia is ventricular arrhythmia.
22. The method of claim 7 , wherein the cardiac arrhythmia is ventricular arrhythmia.
23. The method of claim 12 , wherein the cardiac arrhythmia is ventricular arrhythmia.