IP Library › Granted Patent US 8,361,775
Granted Patent B2
US 8,361,775 · App. 12/466,122 · Granted Jan 29, 2013

Imaging methods and compositions comprising fluorescent dyes associated with viral components for nerve imaging

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Quick Facts
Patent No.
US 8,361,775
App. No.
12/466,122
Granted
Jan 29, 2013
Kind
B2
Abstract

Disclosed herein are compositions and methods for imaging nerve cells. The composition comprises a fluorescent dye; and a viral component selected from a neurotropic, replication-defective virus, a viral protein of a neurotropic virus, and a capsid of a neurotropic virus. Although the fluorescent dye in itself cannot penetrate nerve cells, the fluorescent dye is bound to the viral component to form a dye/viral component complex that is capable of penetrating nerve cells.

Claims (6)

1. A composition comprising:

a fluorescent dye; and

a neurotropic herpes varicellae unable to replicate in nerve cells,

wherein the fluorescent dye is bound to the virus to form a complex that is capable of penetrating nerve cells.

2. The composition of claim 1 , wherein the dye is selected from indocyanine green, infracyanine green, green fluorescent dye, fluorescein isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin, o-phthaldehyde, fluorescamine, Rose Bengal, trypan blue, fluoro-gold, 3-indocyanine-green-acyl-1,3-thiazolidine-thione, green fluorescent protein, red fluorescent protein, yellow fluorescent protein, blue fluorescent protein and other fluorescent proteins.

3. The composition of claim 2 , wherein the dye is indocyanine green.

Assignments (18)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 26, 2023
From: STRYKER EUROPEAN OPERATIONS LIMITED
To: STRYKER CORPORATION
Reel/Frame 066140/0647 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 053823 FRAME: 0445. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 11/29/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS III, LLC
To: STRYKER EUROPEAN HOLDINGS LLC
Reel/Frame 056426/0496 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 052873 FRAME: 0548. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 11/30/2017. Recorded May 3, 2021
From: NOVADAQ TECHNOLOGIES ULC
To: STRYKER EUROPEAN HOLDINGS I, LLC
Reel/Frame 056425/0616 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 052860 FRAME: 0900. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 12/31/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS LLC
To: STRYKER EUROPEAN OPERATIONS LIMITED
Reel/Frame 056426/0585 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 044910 FRAME: 0507. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER AND CHANGE OF NAME. Recorded May 3, 2021
From: NOVADAQ TECHNOLOGIES INC.
To: NOVADAQ TECHNOLOGIES ULC
Reel/Frame 056425/0530 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICAITON NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 053318 FRAME: 0612. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 09/05/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS I, LLC
To: STRYKER EUROPEAN HOLDINGS IV, LLC
Reel/Frame 056425/0731 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 052873 FRAME: 0597. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 09/05/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS IV, LLC
To: STRYKER EUROPEAN HOLDINGS III, LLC
Reel/Frame 056426/0352 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS I, LLC
To: STRYKER EUROPEAN HOLDINGS IV, LLC
Reel/Frame 053318/0612 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS LLC
To: STRYKER EUROPEAN OPERATIONS LIMITED
Reel/Frame 052860/0900 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: NOVADAQ TECHNOLOGIES ULC
To: STRYKER EUROPEAN HOLDINGS I, LLC
Reel/Frame 052873/0548 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS IV, LLC
To: STRYKER EUROPEAN HOLDINGS III, LLC
Reel/Frame 052873/0597 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS III, LLC
To: STRYKER EUROPEAN HOLDINGS LLC
Reel/Frame 053823/0445 →
MERGER AND CHANGE OF NAME Recorded Dec 19, 2017
From: NOVADAQ TECHNOLOGIES INC.; STRYKER CANADA OPERATIONS ULC
To: NOVADAQ TECHNOLOGIES ULC
Reel/Frame 044910/0507 →
RELEASE OF SECURITY INTEREST Recorded Sep 8, 2017
From: MIDCAP FINANCIAL TRUST
To: NOVADAQ TECHNOLOGIES INC.; NOVADAQ CORP.
Reel/Frame 043788/0799 →
RELEASE OF SECURITY INTEREST Recorded Sep 8, 2017
From: MIDCAP FUNDING IV TRUST (AS SUCCESSOR AGENT TO MIDCAP FINANCIAL TRUST)
To: NOVADAQ TECHNOLOGIES INC.; NOVADAQ CORP.
Reel/Frame 043786/0344 →
SECURITY AGREEMENT (TERM) Recorded Jan 9, 2017
From: NOVADAQ TECHNOLOGIES; NOVADAQ CORP.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 041306/0189 →
SECURITY AGREEMENT (REVOLVING) Recorded Jan 9, 2017
From: NOVADAQ TECHNOLOGIES; NOVADAQ CORP.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 041306/0172 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 28, 2009
From: FLOWER, ROBERT W.
To: NOVADAQ TECHNOLOGIES INC.
Reel/Frame 023012/0768 →