(R)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described. Compounds described include those of formula I:
1 - 43 . (canceled)
44 . (R)-(3′-chlorobiphenyl-4-yl)(1-(pyrimidin-2-yl)piperidin-4-yl)methanol or a pharmaceutically acceptable salt thereof.
45 . (canceled)
46 . A pharmaceutical composition comprising the compound of claim 44 and a pharmaceutically acceptable excipient.
47 . A single unit dosage form comprising the pharmaceutical composition of claim 46 .
48 - 57 . (canceled)
57 . A method of treating or managing schizophrenia in a patient, which comprises administering to the patient a therapeutically or prophylactically effective amount of (R)-(3′-chlorobiphenyl-4-yl(1-(pyrimidin-2-yl)piperidin-4-yl)methanol or a pharmaceutically acceptable salt thereof.
58 - 61 . (canceled)