Agent for the prevention and treatment of sexually transmitted diseases-I
View Patent ↗Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted diseases.
1. A method for the therapeutic treatment of sexually transmitted diseases in a human patient comprising administering topically to the patient an effective amount of a compound of the Formula I:
wherein R represents a group of the Formula IV, wherein * indicates the point of attachment:
or a pharmaceutically acceptable salt thereof, and
wherein said disease is a vaginally or rectally transmitted disease selected from the group consisting of HSV-1, HSV-2, HIV-1, HIV-2, HPV and Chlamydia trachomatis infection.
2. The method according to claim 1 , wherein the pharmaceutically acceptable salt is selected from metallic salts, organic salts made from organic amines, quaternary amine salts, sulphonium salts, and phosphonium salts.
3. The method according to claim 2 , wherein said metallic salt is selected from the group consisting of aluminium, calcium, lithium, magnesium, potassium, sodium, zinc salts.
4. The method according to claim 2 , wherein said organic amine is selected from the group consisting of N,N′-dibenzylethylenediamine, chloroprocaine, diethanolamine, ethylenediamine, dicyclohexylamine, meglumine (N-methylglucamine) and procaine.
5. The method according to claim 2 , wherein said quaternary amine salt is choline.