IP Library › Granted Patent US 8,779,090
Granted Patent B2
US 8,779,090 · App. 12/528,737 · Granted Jul 15, 2014

Methods and compositions for the treatment of heart failure and other disorders

Inventors: Daniel Zimmer (Somerville, MA); Angelika Fretzen (Somerville, MA); Mark Currie (Sterling, MA); G. Todd Milne (Brookline, MA)
Assignee: Ironwood Pharmaceuticals, Inc.
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Quick Facts
Patent No.
US 8,779,090
App. No.
12/528,737
Granted
Jul 15, 2014
Kind
B2
Abstract

Peptides that act as GC-C receptor agonists and contain at least one D-cys and are useful for the treatment of diuresis and heart disease as well as other disorders are described.

Claims (1)

1. A method of treating a disorder comprising administering to a patient in need thereof an effective amount of a peptide consisting of the amino acid sequence D-Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Thr Gly Cys wherein said disorder is selected from heart failure, acute heart failure, or chronic heart failure.

Assignments (2)
SECURITY INTEREST Recorded May 22, 2023
From: IRONWOOD PHARMACEUTICALS, INC.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION
Reel/Frame 063711/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 27, 2010
From: ZIMMER, DANIEL; FRETZEN, ANGELIKA; CURRIE, MARK; MILNE, G. TODD
To: IRONWOOD PHARMACEUTICALS INC.
Reel/Frame 024898/0187 →
Continuity (3)
Provisional Application 60891626 · Feb 26, 2007
Related Publication 20110021419A1 · Jan 27, 2011
Related Publication 20120040892A9 · Feb 16, 2012