HIGH-THROUGHPUT PRODUCTION OF INGESTIBLE EVENT MARKERS
High-throughput ingestible event marker manufacturing systems are provided. The systems include an assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product. Also provided are manufacturing methods to produce such products which include assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier.
1 . A high-throughput system comprising an automated assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product.
2 . The system according to claim 1 , wherein the assembly unit is configured to stably associate an ingestible event marker with a pre-made carrier.
3 . The system according to claim 2 , wherein the assembly unit is configured to stably associate the ingestible event marker with the pre-made carrier using an adhesive.
4 . The system according to claim 2 , wherein the ingestible event marker includes an element that mechanically provides for stable association with the pre-made carrier.
5 . The system according to claim 2 , wherein the assembly unit is configured to print one or more components of the ingestible event marker on a surface of the pre-made carrier.
6 . The system according to claim 1 , wherein the assembly unit is configured to produce a product from an ingestible event marker and a carrier precursor.
7 . The system according to claim 1 , wherein the assembly unit is configured to associate a coating with the ingestible event marker.
8 . The system according to claim 7 , wherein the coating is opaque and is configured to hide the ingestible event marker associated with the carrier.
9 . The system according to claim 1 , wherein the assembly unit is integrated with a packaging unit of the system.
10 . The system according to claim 1 , wherein the system comprises an element selected from the group consisting essentially of:
an ingestible event marker manufacturing unit to manufacture ingestible event marker;
a quality control inspection unit to inspect the ingestible event marker;
a programming device to program the ingestible event marker of the product;
a signature element unit to associate a signature with the ingestible event marker; and
a packaging unit to produce packages associated with the ingestible event markers.
11 . A high-throughput method for producing a product, the method comprising:
assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier to produce the product.
12 . The method according to claim 11 , wherein the assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product comprises:
compressing a carrier with the ingestible event marker to form the product.
13 . The method according to claim 11 , further comprising:
coating at least a portion of the ingestible event marker.
14 . The method according to claim 11 , further comprising:
printing to deposit one or more components of the ingestible event marker onto at least a portion of the carrier.
15 . The method according to claim 11 , further comprising:
packaging the product.
16 . The method according to claim 15 , wherein the packaging the ingestible event marker further comprises:
bulk packaging multiple products.
17 . The method according to Clam 16 , further comprising:
repackaging the bulk-packaged products.
18 . The method according to claim 11 , wherein the assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker identifier with a carrier to produce an ingestible event marker comprises:
mechanically attaching the ingestible event marker to the carrier.
19 . The method according to claim 18 , further comprising:
overcoating at least a portion of the ingestible event marker.
20 . method according to claim 11 , wherein the assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier to produce an ingestible event marker comprises:
inserting an ingestible event marker into a carrier.
21 . A process for manufacturing an identifiable product that includes a pharmaceutical agent and an ingestible device, the process comprising the step of presenting the pharmaceutical agent in the form of a tablet to an assembly unit, wherein the assembly unit manufactures the identifiable product through the steps comprising:
placing a determined volume of adhesive onto one surface of the tablet to produce an adhesive sided tablet using an adhesive delivery unit; and
securing the ingestible device to the adhesive sided tablet to produce the identifiable product using a device delivery unit.
22 . The process of claim 21 , wherein the assembly unit further performs a step including placing a protective coating onto the identifiable product to produce a coated identifiable product using a protective coating delivery unit.
23 . A process for manufacturing an identifiable product from a pharmaceutical agent and an ingestible device using an assembly unit that includes a powder delivery unit, a compressing unit, and a device delivery unit, the process comprising the steps of:
delivering a first portion powder form of the pharmaceutical agent to a tablet die of the assembly unit using the powder delivery unit;
placing the ingestible device into the tablet die of the assembly unit using the device delivery unit;
delivering a second portion powder form of the pharmaceutical agent to the tablet die of the assembly unit; and
compressing the content of the tablet die using the compressing unit to form the identifiable product.
24 . A process for manufacturing an identifiable product using an assembly apparatus that includes a first capsule portion delivery unit, a capsule assembler unit, an agent delivery unit, and a device delivery unit, the process comprising the steps of:
delivering a first portion of a capsule using the first capsule portion delivery unit of the assembly apparatus;
filling the first portion of the capsule with a pharmaceutical agent using the agent delivery unit of the assembly apparatus;
placing an ingestible device into the first portion of the capsule using the device delivery unit of the assembly apparatus; and
sealing the content of the first portion of the capsule with a second portion of the capsule using the capsule assembler unit of the assembly apparatus.