Intraocular Lens
An intraocular lens comprising: (a) monomeric units derived from at least one cationically polymerizable branched alkene monomer; (b) monomeric units derived from at least one cationically polymerizable monomer having a pendant benzocyclobutene group; and (c) a UV-absorbing benzotriazole component having the formula I.
1 . An intraocular lens comprising: (a) monomeric units derived from at least one cationically polymerizable branched alkene monomer; (b) monomeric units derived from at least one cationically polymerizable monomer having a pendant benzocyclobutene group; and (c) a UV-absorbing benzotriazole component having the formula I
wherein R 1 and R 2 are independently selected from hydrogen, methyl, ethyl, propyl, iso-propyl, a C 4 -C 10 branched alkyl with one or two optional ether linkages, C 2 -C 16 alkylene with one or two optional ether or aromatic linkages and —NHCOR 4 , wherein R 4 is a C 4 -C 10 branched alkyl with one or two optional ether linkages or C 2 -C 16 alkylene with one or two optional ether or aromatic linkages, and at least one of R 1 , R 2 and R 4 is a C 2 -C 16 alkylene with one or two optional ether or aromatic linkages; and R 3 is hydrogen, —OCH 3 , —OC 2 H 5 , fluoro, chloro, bromo or iodo.
2 . The intraocular lens according to claim 1 , further comprising monomeric units derived from at least one glass-forming monomer.
3 . The intraocular lens according to claim 1 or 2 , wherein the at least one branched alkene monomer is an isoolefin.
4 . The intraocular lens according to any one of claims 1 to 3 , wherein the isoolefin is isobutylene.
5 . The intraocular lens according to any one of claims 1 to 4 , wherein the monomer having a pendant benzocyclobutene group has the formula
R is hydrogen or an alkyl group and n is an integer selected from 0, 1, 2 or 3.
6 . The intraocular lens according to any one of claims 1 to 5 , wherein the monomer having a pendant benzocyclobutene group is selected from the group consisting of 4-vinylbenzocyclobutene, 2-(4-benzocyclobutenyl)-propene, and 2-methyl-3-(4-benzocyclobutenyl)-propene.
7 . The intraocular lens according to any one of claims 2 to 6 , wherein the glass-forming monomer is present and selected from the group consisting of styrene, indene, α-methylstyrene, p-tert-butylstyrene, p-chlorostyrene, p-methoxystyrene, p-tert-butoxystyrene, p-hydroxystyrene, norbornene, and any one mixture thereof.
8 . The intraocular lens according to any one of claims 2 to 7 , wherein the alkene monomer is isobutylene, the monomer having a pendant benzocyclobutene group is
4-vinylbenzocyclobutene, and the glass-forming monomer is present and is styrene.
9 . The intraocular lens according to any one of claims 1 to 8 , wherein the UV-absorbing benzotriazole component has at least one of R 1 , R 2 and R 4 as a C 6 -C 10 branched alkyl.
10 . The intraocular lens according to any one of claims 1 to 9 , wherein the UV-absorbing benzotriazole component is of formula
11 . The intraocular lens according to any one of claims 1 to 9 , wherein the UV-absorbing benzotriazole component is of formula
12 . The intraocular lens according to any one of claims 1 to 9 , wherein the UV-absorbing benzotriazole component is of formula
wherein R 5 is methyl, ethyl, propyl or iso-propyl.
13 . The intraocular lens according to any one of claims 1 to 12 , wherein the lens has an index of refraction from 1.52 to 1.55.
14 . The intraocular lens according to any one of claims 1 to 13 , further comprising hinges between the haptics and the outer periphery of the optic to allow the optic to move forward with the increase in vitreous cavity pressure.
15 . The intraocular lens according to claim 14 , wherein the hinges have a hinge width of 0.4 mm to 6.0 mm, a hinge base width of 0.1 mm to 0.8 mm, and a hinge thickness of 0.06 mm to 0.4 mm.
16 . The intraocular lens according to claim 14 or 15 , wherein the optic is an asymmetrical optic of substantially greater dimension transversely of the longitudinal direction and of lesser dimension in the longitudinal direction.