COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, AMELIORATING, OR PREVENTING ALLERGY
A composition for treating, controlling, reducing, ameliorating, or preventing allergy comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an anti-allergic medicament and/or an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. The anti-allergic medicament can comprise an antihistamine, a mast-cell stabilizer, a leukotriene inhibitor, an immunomodulator, an anti-IgE agent, or a combination thereof.
1 . A method for treating, controlling, reducing, ameliorating, or alleviating an infection and sequelae thereof, the method comprising: (a) providing a composition comprising: (i) a DIGRA having Formula IV, or a pharmaceutically acceptable salt thereof; and (b) administering to a subject an amount of the composition at a frequency sufficient to treat, control, reduce, ameliorate, or alleviate the condition or disorder in the subject
2 . The method of claim 1 , wherein the method results in a lower level of side effect than a method using dexamethasone for treating, controlling, reducing, ameliorating, or alleviating the same condition.
3 . The method of claim 41 , wherein the composition further comprises an additional anti-inflammatory agent.
4 . The method of claim 3 , wherein said additional anti-inflammatory agent is selected from the group consisting of NSAIDs, PPAR ligands, combinations thereof, and mixtures thereof.
5 . The method of claim 1 , wherein the composition further comprises an anti-allergic material.
6 . The method of claim 5 , wherein the method results in a lower level of side effect than a method using dexamethasone for treating, controlling, reducing, ameliorating, or alleviating the same condition.
7 . The method of claim 6 , wherein the anti-allergic material comprises a H 1 -receptor antagonist.