Controlled-released peptide formulations
View Patent ↗Described herein are methods and compositions for modulating the release and/or drug loading characteristics of encapsulated bioactive agents in polymer-based delivery systems via direct modification of the isoelectric point and/or net charge of the bioactive agent.
1. A controlled-release pharmaceutical formulation comprising a modified bioactive agent encapsulated by a polymer selected from poly(lactide-co-glycolide), poly(lactide), poly(glycolide), polycaprolactone, poly(lactide-co-caprolactone), poly(lactide-co-glycolide-co-caprolactone), poly(glycolide-co-caprolactone), or a mixture thereof, wherein said modified bioactive agent is a peptide having the amino acid sequence selected from the group consisting of: SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:9.
2. The controlled-release pharmaceutical formulation according to claim 1 , wherein said polymer is poly(lactide-co-glycolide).
3. The controlled-release pharmaceutical formulation according to claim 1 or 2 , wherein said modified bioactive agent is a peptide having the amino acid sequence set forth in SEQ ID NO:2.
4. The controlled-release pharmaceutical formulation according to claim 1 or 2 , wherein said modified bioactive agent is a peptide having the amino acid sequence set forth in SEQ ID NO:3.
5. The controlled-release pharmaceutical formulation according to claim 1 or 2 , wherein said modified bioactive agent is a peptide having the amino acid sequence set forth in SEQ ID NO:4.
6. The controlled-release pharmaceutical formulation according to claim 1 or 2 , wherein said modified bioactive agent is a peptide having the amino acid sequence set forth in SEQ ID NO:6.
7. The controlled-release pharmaceutical formulation according to claim 1 or 2 , wherein said modified bioactive agent is a peptide having the amino acid sequence set forth in SEQ ID NO:7.
8. The controlled-release pharmaceutical formulation according to claim 1 or 2 , wherein said modified bioactive agent is a peptide having the amino acid sequence set forth in SEQ ID NO:9.