COMPOSITIONS COMPRISING A SHELF-LIFE STABILITY COMPONENT
Compositions that include a shelf-life stability component are provided. In some instances, the compositions are ingestible compositions which include the shelf-life stability component and an ingestible component. Aspects of the invention further include methods of making and using the compositions.
1 . A composition comprising a shelf-life stability component physically associated with a minimally dimensioned component.
2 . The composition according to claim 1 , wherein the composition is an ingestible composition comprising the shelf-life stability component and an ingestible component physically associated with the ingestible composition.
3 . The ingestible composition according to claim 2 , wherein the composition further comprises an ingestible device.
4 . The ingestible composition according to claim 3 , wherein the ingestible device is an ingestible event marker.
5 . The composition according to claim 1 , wherein the ingestible composition is stable for 1 year or longer under conditions in which the temperature ranges from 10 to 40° C., the pressure ranges from 0.5 to 2.0 ATM and the relative humidity ranges from 10 to 100%.
6 . The composition according to claim 1 , wherein the shelf-life stability component comprises a water-vapor desensitizer.
7 . The composition according to claim 5 , wherein the water-vapor desensitizer comprises a protective barrier that rapidly disrupts upon contact with a liquid.
8 . The composition according to claim 7 , wherein the protective barrier comprises a homogeneous layer of a single material.
9 . The composition according to claim 7 , wherein the protective barrier comprises two or more distinct materials.
10 . The composition according to claim 9 , wherein the two or more distinct materials are present as a single homogeneous or heterogeneous layer.
11 . The composition according to claim 9 , wherein the two or more distinct materials are present as a multilayer structure.
12 . The composition according to claim 9 , wherein the two or more distinct materials exhibit different aqueous medium solubility.
13 . The composition according to claim 9 , wherein the two or more distinct materials exhibit different aqueous medium physical properties.
14 . The composition according to claim 9 , wherein the two or more distinct materials comprise a first material and a second material that solubilizes the first material.
15 . The composition according to claim 7 , wherein the protective barrier comprises a lipid.
16 . The composition according to claim 7 , wherein the protective barrier comprises a low-melting point material.
17 . The composition according to claim 7 , wherein the protective barrier is a galvanic protective barrier.
18 . The composition according to claim 7 , wherein the protective barrier is configured to be disruptable by a device present in the composition.
19 . The composition according to claim 7 , wherein the protective barrier is configured to provide aqueous liquid passage through the protective barrier upon contact of ingestible composition with an aqueous liquid.
20 . The composition according to claim 7 , wherein the protective barrier comprises a liquid passageway.
21 . The composition according to claim 6 , wherein the water-vapor desensitizer comprises a desiccant.
22 . The composition according to claim 1 , wherein minimally dimensioned component is a micro-battery.
23 . A system comprising:
an ingestible composition comprising:
a shelf-life stability component; and
an ingestible component associated with the shelf-life stability component; and
a receiver configured to receive a communication associated with the ingestible composition.
24 . A method comprising combining a minimally dimensioned component and a shelf-life stability component.
25 . The method according to claim 24 , wherein the minimally dimensioned component is an ingestible component and the method produces an ingestible composition.
26 . The method according to claim 25 , wherein the method comprises stably associating the ingestible component and the shelf-life stability component.
27 . The method according to claim 26 , wherein the method comprises one or more protocols selected from the group consisting of laminating, pressing, stamping, extruding, molding and coating.
28 . The method according to claim 27 , wherein at least a portion of the method is automated.