RFID Antenna for In-Body Device
RFID antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include RFID signal transmission antennas with a battery that is activated upon being exposed to fluid in the body. Embodiments of the RFID antennas are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
1 . An ingestible event marker comprising an identifier that emits a signal when activated at a target site, wherein said identifier comprises a signal generation element comprising a RFID antenna.
2 . The ingestible event marker according to claim 1 , wherein said identifier is activated upon contact with fluid at said target site.
3 . The ingestible event marker according to claim 2 , wherein said target fluid is stomach fluid.
4 . The ingestible event marker according to claim 1 , wherein said identifier comprises a power source.
5 . The ingestible event marker according to claim 4 , wherein said power source comprises a battery.
6 . The ingestible event marker according to claim 4 , wherein said power source comprises a Galvanic cell.
7 . The ingestible event marker according to claim 1 , wherein an input signal to said RFID antenna is provided by a reader.
8 . The ingestible event marker according to claim 1 , wherein an input signal to said RFID antenna is provided by a battery.
9 . The ingestible event marker according to claim 1 , wherein said identifier has a limited lifespan.
10 . The ingestible event marker according to claim 1 , wherein said RFID antenna is configured to conform to ingestible pill dimensions.
11 . The ingestible event marker according to claim 1 , wherein said RFID antenna has a first configuration prior to ingestion and a second configuration after ingestion.
12 . The ingestible event marker according to claim 11 , wherein said RFID antenna unfolds after ingestion.
13 . The ingestible event marker according to claim 11 , wherein said RFID antenna has a greater effective area in said second configuration than in said first configuration.
14 . The ingestible event marker according to claim 1 , wherein said identifier comprises an integrated circuit.
15 . The ingestible event marker according to claim 1 , further comprising an active agent stably associated with said signal generation element.
16 . A system comprising:
(a) an ingestible event marker comprising an identifier that emits a signal when activated at a target site, wherein said identifier comprises a signal generation element comprising a RFID antenna; and
(b) a receiver for detecting a signal produced by said signal generation element.
17 . The system according to claim 16 , wherein said receiver is an in vivo receiver.
18 . The system according claim 16 , wherein said receiver is an ex vivo receiver.
19 . A method comprising: administering to a subject an ingestible event marker comprising an identifier that emits a signal when activated at a target site, wherein said identifier comprises a signal generation element comprising a RFID antenna.
20 . A kit comprising: at least one ingestible event marker comprising an identifier that emits a signal when activated at a target site, wherein said identifier comprises a signal generation element comprising a RFID antenna.
21 . The kit according to claim 20 , wherein said kit comprises a plurality of said ingestible event markers.
22 . The kit according to claim 20 , wherein said kit further comprises a receiver.
23 . An in-body device comprising a RFID antenna.
24 . The in-body device according to claim 23 , wherein said in-body device is an ingestible device.
25 . The in-body device according to claim 23 , wherein said in-body device is an implantable device.