PHARMACEUTICAL SOLUTION OF CETIRIZINE HYDROCHLORIDE
A pharmaceutical solution comprising cetirizine hydrochloride, an alcohol compound with less than 3 carbon atoms, a preservative and urea is disclosed. The cetirizine hydrochloride is in racemic form or in levo form.
1 . A pharmaceutical solution of cetirizine hydrochloride, characterized by comprising the following components:
Cetirizine hydrochloride
0.1~2
parts by weight;
Alcohol having 3 or less carbon atoms
1-50
parts by weight;
Preservative
0.01~0.2
parts by weight;
Urea
0.02~20
parts by weight; and
Inorganic salt
0~5
parts by weight,
Wherein said cetirizine hydrochloride is racemic cetirizine hydrochloride or L-cetirizine hydrochloride.
2 . The pharmaceutical solution according to claim 1 , characterized by comprising the following components:
Cetirizine hydrochloride
0.2~2
parts by weight;
Alcohol having 3 or less carbon atoms
10-40
parts by weight;
Preservative
0.01~0.2
parts by weight;
Urea
1~5
parts by weight; and
Inorganic salt
0~5
parts by weight,
Wherein said cetirizine hydrochloride is L-cetirizine hydrochloride.
3 . The pharmaceutical solution according to claim 2 , characterized by comprising the following components:
L-cetirizine hydrochloride
0.5~1.5
parts by weight;
Alcohol having 3 or less carbon atoms
15-40
parts by weight;
Preservative
0.05~0.2
parts by weight;
Urea
1~3
parts by weight; and
Inorganic salt
0~5
parts by weight.
4 . The pharmaceutical solution according to claim 3 , characterized by comprising the following components:
L-cetirizine hydrochloride
1
part by weight;
Alcohol having 3 or less carbon atoms
15-40
parts by weight;
Preservative
0.1
parts by weight;
Urea
2
parts by weight; and
Inorganic salt
0.5~1.5
parts by weight.
5 . The pharmaceutical solution according to claim 1 , characterized in that said alcohol having 3 or less carbon atoms is propanediol, glycerin, propanol, ethanol or any combination thereof; said preservative is one or two selected from benzalkonium bromide, chlorhexidine acetate, sodium benzoate and sorbic acid; and said inorganic salt is one or more selected from sodium chloride, potassium chloride, sodium sulfate, potassium sulfate, calcium chloride and sodium bicarbonate.
6 . The pharmaceutical solution according to claim 5 , characterized in that said alcohol having 3 or less carbon atoms is glycerin or 1,2-propanediol; said preservative is benzalkonium bromide or chlorhexidine acetate; and said inorganic salt is sodium chloride.
7 . The pharmaceutical solution according to claim 6 , characterized in that said alcohol having 3 or less carbon atoms is glycerin and said preservative is benzalkonium bromide.
8 . The pharmaceutical solution according to claim 1 , characterized in that the pH of the pharmaceutical solution is 5.0˜7.0.
9 . The pharmaceutical solution according to claim 8 , characterized in that the pH of the pharmaceutical solution is 6.0.
10 . The pharmaceutical solution according to claim 1 , characterized in that said pharmaceutical solution is liniment, drops, aerosol or spray.
11 . The pharmaceutical solution according to claim 5 , characterized in that said pharmaceutical solution further comprises a flavoring agent which is orange peel oil, anise oil, citron oil, citron tincture, a fragrant, cinnamon water, cinnamon oil, banana essence, orange essence, lemon essence or apple essence.
12 . The pharmaceutical solution according to claim 1 , characterized by comprising the following components:
Cetirizine hydrochloride
0.1~2
parts by weight;
Alcohol having 3 or less carbon atoms
1-50
parts by weight;
Preservative
0.02~0.2
parts by weight;
Urea
0.02~20
parts by weight; and
Inorganic salt
0.01~2
parts by weight,
wherein said cetirizine hydrochloride is racemic cetirizine hydrochloride, said alcohol having 3 or less carbon atoms is glycerin; said preservative is benzalkonium bromide; and said inorganic salt is sodium chloride.
13 . The pharmaceutical solution according to claim 12 , characterized by comprising the following components:
Cetirizine hydrochloride
0.5~1.5
parts by weight;
Glycerin
5-40
parts by weight;
Urea
1~6
parts by weight;
Benzalkonium bromide
0.02~0.15
parts by weight; and
Sodium chloride
0.5~1.5
parts by weight.
14 . The pharmaceutical solution according to claim 13 , characterized by comprising the following components:
Cetirizine hydrochloride
1
part by weight;
Glycerin
35-40
parts by weight;
Urea
1~3
parts by weight;
Benzalkonium bromide
0.08~0.12
parts by weight; and
Sodium chloride
0.5~1.5
parts by weight.
15 . The pharmaceutical solution according to claim 14 , characterized by comprising the following components:
Cetirizine hydrochloride
1
part by weight;
Glycerin
37.8
parts by weight;
Urea
2
parts by weight;
Benzalkonium bromide
0.1
parts by weight; and
Sodium chloride
0.9
parts by weight.
16 . The pharmaceutical solution according to claim 12 , characterized in that the pH of the pharmaceutical solution is 4.0˜7.5.
17 . The pharmaceutical solution according to claim 16 , characterized in that the pH is 5.0˜7.0.