Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
1 . A compound selected from the following table:
#
Compound
3
4
6
7
9
16
17
18
22
23
24
26
27
28
29
33
36
38
43
47
50
51
55
58
61
66
67
68
71
74
75
81
88
89
90
91
92
93
94
95
96
103
104
109
110
112
117
118
121
123
124
127
129
131
132
134
135
137
138
139
140
141
143
148
149
151
158
161
162
163
164
165
166
167
168
170
171
172
173
174
175
177
182
186
250
258
273
278
279
294
302
303
312
313
314
315
316
317
339
342
345
350
353
356
357
360
361
364
365
368
370
373
375
376
380
383
388
391
393
395
398
399
400
403
406
409
410
411
412
413
414
415
416
417
418
419
420
421
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
488
489
490
491
492
495
497
498
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
539
542
543
544
545
546
547
548
549
551
552
553
554
555
556
558
559
560
561
565
566
567
569
570
571
572
573
578
580
584
586
587
590
591
593
594
595
596
598
599
600
601
602
603
604
606
608
609
610
613
614
623
624
625
626
627
645
646
697
698
699
701
702
703
717
718
719
720
728
729
730
731
732
733
734
735
736
737
738
739
748
749
750
751
752
753
754
755
756
757
758
759
760
771
772
773
or a pharmaceutically acceptable salt thereof.
2 - 75 . (canceled)
76 . A pharmaceutical composition comprising a compound according to claim 1 , and a pharmaceutically acceptable adjuvant or carrier.
77 - 116 . (canceled)