IP Library Granted Patent US 8,774,926
Granted Patent B2
US 8,774,926 · App. 13/705,045 · Granted Jul 8, 2014

Multi-frequency neural treatments and associated systems and methods

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Quick Facts
Patent No.
US 8,774,926
App. No.
13/705,045
Granted
Jul 8, 2014
Kind
B2
Abstract

Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.

Claims (38)

1. A method for alleviating patient pain or discomfort, without using paresthesia or tingling to mask the patient's sensation of pain or discomfort, the method comprising:

directing a lead having at least one electrode into the patient's epidural space;

positioning the at least one electrode proximate to the patient's dorsal root ganglion and outside the sacral region;

applying an electrical therapy signal to the patient's dorsal root ganglion via the at least one electrode,

wherein at least a portion of the therapy signal is at a frequency in a frequency range of from about 2,500 Hz to about 100,000 Hz, and

wherein the electrical therapy signal inhibits or prevents the patient's sensation of pain.

2. The method of claim 1 , wherein the frequency range is from about 2,500 Hz to about 20,000 Hz.

3. The method of claim 1 , wherein the frequency range is from about 3,000 Hz to about 10,000 Hz.

4. The method of claim 1 , wherein the at least one electrode is disposed toward a distal end of a lead.

5. The method of claim 1 , further comprising:

applying a low frequency stimulation signal to the patient's spinal cord region.

6. The method of claim 1 wherein the electrical therapy signal has an amplitude of up to 20 mA.

7. The method of claim 1 wherein the electrical therapy signal is applied continuously.

8. The method of claim 1 wherein the electrical therapy signal is applied discontinuously so as to include periods when the electrical therapy signal is applied, and periods when the electrical therapy signal is terminated according to a duty cycle.

9. The method of claim 8 wherein the duty cycle is less than 50%.

10. The method of claim 1 wherein the electrical therapy signal is applied discontinuously so as to include periods when the electrical therapy signal is applied, and periods when the electrical therapy signal is terminated.

11. The method of claim 10 wherein the periods when the electrical therapy signal is applied range from a few seconds to a few hours.

12. A method for alleviating a patient's pain or discomfort, without relying on paresthesia or tingling to mask the patient's sensation of the pain or discomfort, comprising:

directing a lead having at least one electrode into the patient's epidural space;

positioning the at least one electrode proximate to the patient's dorsal root ganglion and outside the sacral region;

electrically coupling the electrode to a signal generator; and

programming the signal generator to generate and deliver an electrical therapy signal to the dorsal root ganglion, via the at least one electrode, wherein at least a portion of the electrical therapy signal is at a frequency in a frequency range of from about 2,500 Hz to about 100,000 Hz.

13. The method of claim 12 , further comprising:

applying a low frequency stimulation signal to the patient's spinal cord region.

14. The method of claim 13 , wherein the low frequency stimulation signal is at a frequency in a frequency range of from about 40 Hz to about 500 Hz.

15. The method of claim 13 , wherein the low frequency stimulation signal induces paresthesia.

16. The method of claim 15 , wherein the electrical therapy signal alleviates the patient's discomfort resulting from the paresthesia.

17. The method of claim 12 , wherein the lead includes a percutaneous lead, and wherein the at least one electrode is positioned toward a distal end of the percutaneous lead.

18. The method of claim 12 , further comprising:

coupling the lead to an implantable signal generator configured to generate the electrical therapy signal.

19. The method of claim 12 , wherein at least a portion of the electrical therapy signal is at a frequency in a frequency range of from about 2,500 Hz to about 20,000 Hz.

20. The method of claim 12 , wherein at least a portion of the electrical therapy signal is at a frequency in a frequency range of from about 3,000 Hz to about 10,000 Hz.

21. The method of claim 12 wherein the electrical therapy signal has an amplitude of up to 20 mA.

22. The method of claim 12 wherein the electrical therapy signal is applied continuously.

23. The method of claim 12 wherein the electrical therapy signal is applied discontinuously so as to include periods when the electrical therapy signal is applied, and periods when the electrical therapy signal is terminated according to a duty cycle.

24. The method of claim 23 wherein the duty cycle is less than 50%.

25. The method of claim 12 wherein the electrical therapy signal is applied discontinuously so as to include periods when the electrical therapy signal is applied, and periods when the electrical therapy signal is terminated.

26. The method of claim 25 wherein the periods when the electrical therapy signal is applied range from a few seconds to a few hours.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded Apr 4, 2025
From: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
To: NEVRO CORP.
Reel/Frame 070743/0001 →
PATENT SECURITY AGREEMENT Recorded Dec 1, 2023
From: NEVRO CORP.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 065744/0302 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNMENT PREVIOUSLY RECORDED AT REEL: 030882 FRAME: 0521. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY DATA NAME.. Recorded Dec 18, 2017
From: FANG, ZI-PING; CAPARSO, ANTHONY V.; ERICKSON, BRIAN J.; ALATARIS, KONSTANTINOS; WALKER, ANDRE B.
To: NEVRO CORP.
Reel/Frame 044905/0050 →
RELEASE OF SECURITY INTEREST Recorded Jun 27, 2016
From: CRG SERVICING LLC
To: NEVRO CORP.
Reel/Frame 039168/0890 →
ASSIGNMENT AGREEMENT (REAFFIRMATION) Recorded Jun 13, 2016
From: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.
To: CRG SERVICING LLC,
Reel/Frame 038984/0865 →
SECURITY INTEREST Recorded Dec 12, 2014
From: NEVRO CORP.
To: CAPITAL ROYALTY PARTNERS II L.P.; CAPITAL ROYALTY PARTNERS II - PARALLEL FUND "A" L.P.; PARALLEL INVESTMENT OPPORTUNITIES PARTNERS II L.P.
Reel/Frame 034619/0546 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 26, 2013
From: FANG, ZI-PING; CAPARSO, ANTHONY V.; ERICKSON, BRIAN J.; ALATARIS, KONSTANTINOS; WALKER, ANDRE B.
To: NEVRO CORPORATION
Reel/Frame 030882/0521 →