Sodium glucose co-transporter inhibitors and methods of their use

Inventors: Bryce Alden Harrison (Hamilton, NJ); Spencer David Kimball (East Windsor, NJ); Ross Mabon (Lambertville, NJ); David Brent Rawlins (Morrisville, PA)

Assignee: Lexicon Pharmaceuticals, Inc.

C07H15/14 A61K31/7028 A61K31/7032 C07D211/46 C07D309/10 C07D335/02 C07D407/12 C07H7/04

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Quick Facts

Patent No.: US 9,365,602
App. No.: 13/925,981
Granted: Jun 14, 2016
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.

Claims (2)

1. A method of treating or managing type 1 diabetes, which comprises administering to a patient in need thereof a therapeutically effective amount of (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6-methylsulfanyl-tetrahydro-pyran-3,4,5-triol:

or a pharmaceutically acceptable salt thereof.

Assignments (7)

RELEASE OF SECURITY INTEREST Recorded May 5, 2026

From: OXFORD FINANCE LLC

To: LEXICON PHARMACEUTICALS, INC.; LEXICON PHARMACEUTICALS

Reel/Frame 075545/0601 →

SECURITY INTEREST Recorded May 4, 2026

From: LEXICON PHARMACEUTICALS, INC.; LEXICON PHARMACEUTICALS (NEW JERSEY), INC.; LION ACQUISITION CORPORATION

To: HERCULES CAPITAL, INC., AS AGENT

Reel/Frame 075498/0899 →

SECURITY INTEREST Recorded Mar 17, 2022

From: LEXICON PHARMACEUTICALS, INC.