Collagen fiber ribbons with integrated fixation sutures and methods of making the same
The disclosure describes implantable bioprosthesis and constructs having an implantable woven ribbon with at least one integrated suture.
1. A medical ribbon, comprising:
a woven ribbon body of a plurality of warp yarns and at least one weft yarn, the yarns each comprising continuous lengths of elongate collagen fibers, wherein the ribbon body has a length dimension with opposing first and second end portions spaced apart in the length dimension and connected by transversely spaced apart first and second long sides defining a width dimension; and
at least one suture woven into the ribbon body and oriented to extend in a linear orientation along the length dimension of the ribbon body, wherein the at least one suture extends a length beyond both the first and second end portions of the ribbon body,
wherein the at least one suture is held in a straight linear orientation and under only the at least one weft yarn so that the at least one suture is visible on only a first primary surface of the ribbon body, wherein the at least one weft yarn terminates at the first and second end portions of the ribbon body, and wherein the at least one suture is spaced laterally inward from an outer edge of the first and second long sides of the ribbon body and extends out from the ribbon body while other adjacent warp yarns closer to the first and second long sides of the ribbon body terminate at the first and second end portions of the ribbon body.
2. The ribbon of claim 1 , wherein the at least one weft yarn crosses over the at least one suture once every 1 mm to every 1 inch along at least a major portion of the length of the ribbon body.
3. The ribbon of claim 1 , wherein the at least one weft yarn comprises a plurality of cross-linked collagen fibers that cross over the suture in a regular repeating pattern over at least a major portion of the length of the ribbon body.
4. The ribbon of claim 1 , wherein the at least one suture is a single suture that is woven to the ribbon body proximate a longitudinally extending centerline of the ribbon body.
5. The ribbon of claim 1 , wherein the at least one suture is defined by a subset of the plurality of warp yarns that have a length that is at least 50% longer than others of the plurality of warp yarns of the ribbon body, and wherein the warp yarns defining the at least one suture comprise cross-linked synthetic collagen fibers.
6. The ribbon of claim 5 , wherein tails of the suture warp yarns are braided together outside the ribbon body.
7. The ribbon of claim 1 , wherein the at least one suture is a plurality of sutures, at least one of which extends proximate each of the first and second long sides of the ribbon body.
8. The ribbon of claim 1 , wherein the at least one suture comprises four separate sutures, two parallel sutures attached to and extending along the length dimension on one side of a longitudinally extending centerline of the ribbon body and two parallel sutures attached to and extending along the length dimension on an opposing side of the centerline of the ribbon body.
9. The ribbon of claim 1 , wherein the warp fibers and at least one weft fiber comprise NDGA-polymerized collagen fibers.
10. The ribbon of claim 1 , wherein some of the yarns comprise collagen fibers cross-linked with NDGA and other yarns comprise collagen fibers cross-linked with a different agent.
11. The ribbon of claim 1 , wherein some of the warp yarns and/or the at least one well yarn comprise collagen fibers cross-linked with NDGA and some of the warp yarns and/or the at least one well yarn comprise collagen fibers cross-linked with a different agent.
12. The ribbon of claim 1 , wherein the ribbon has a greater number of warp yarns than well yarns.
13. The ribbon of claim 1 , wherein the at least one suture comprises at least one NDGA-treated or carbodiimide cross-linked collagen fiber.
14. The ribbon of claim 1 , wherein the at least one suture comprises at least four cross-linked collagen fiber sutures, with at least two being laterally spaced apart and extending parallel to and along the length dimension on one side of a longitudinally extending centerline of the ribbon body and at least another two being laterally spaced apart and extending parallel and along the length dimension on an opposing side of the centerline of the ribbon body.
15. The ribbon of claim 1 , wherein the warp yarns and the at least one well yarn comprise cross-linked synthetic collagen fibers, and wherein the at least one suture comprises a plurality of cross-linked synthetic collagen fibers.
16. The ribbon of claim 1 , wherein the at least one suture is defined by a plurality of yarns comprising cross-linked synthetic collagen fibers that define warp yarns of the ribbon body and extend only along the length dimension of the ribbon body and have a length sufficient to extend outwardly therefrom to define tail segments that have a length of between about 2 inches to about 15 inches.
17. The ribbon of claim 10 , wherein the different agent is EDC, and wherein the EDC collagen fibers degrade faster than the NDGA collagen fibers.
18. The ribbon of claim 1 , wherein some of the collagen warp fibers and the at least one weft collagen fiber comprises carbodiimide cross-linked collagen fibers.