Sleep detection for controlling continuous positive airway pressure therapy
A method for detecting sleep for continuous positive airway pressure (CPAP) therapy is disclosed. Discrete values of a control signal generated by a pressure controller to regulate delivered pressure at the patient are measured over a predefined time window encompassing one or more respiratory cycles. A baseline control signal value is generated from a weighted average of the measured discrete values of the control signal. Estimates of a respiratory cycle period, an inspiration control time, and an expiration control time are then generated. Estimates of one or more secondary control signal properties for each of the respective inspiration control time and expiration control time are generated. Pressure to the patient is increased in response to an evaluation of the estimates of the one or more secondary control signal properties being indicative of the patient reaching a sleep state.
1. A method for continuous positive airway pressure (CPAP) therapy comprising:
measuring, over a predefined time window encompassing one or more respiratory cycles, discrete values of a control signal generated by a pressure controller to regulate delivered pressure at the patient;
generating a baseline control signal value from a weighted average of the measured discrete values of the control signal;
generating estimates of a respiratory cycle period, an inspiration control time, and an expiration control time, the inspiration control time being defined as a first duration during which the discrete values of the control signal exceed the baseline control signal, and the expiration control time being defined as a second duration during which the discrete values of the control signal are less than the baseline control signal;
generating estimates of one or more secondary control signal properties for each of the respective inspiration control time and expiration control time over at least one of the one or more respiratory cycles within the predefined time window, the one or more secondary control signal properties including work of breathing values derived from the control signal for the inspiration control time and the expiration control time respectively, the work of breathing values being defined as the area between the control signal and the baseline control signal; and
increasing pressure to the patient in response to an evaluation of the estimates of the work of breathing values indicative of the patient reaching a sleep state.
2. The method of claim 1 , further comprising:
deriving, over the predefined time window, mean and standard deviation values of the estimates of the work of breathing values;
wherein the evaluation of the estimates of the work of breathing values includes a comparison of the mean and standard deviation values of at least one of the estimates of the work of breathing values to corresponding predefined threshold values thereof.
3. The method of claim 1 , wherein the evaluation of the estimates of the work of breathing values includes:
deriving a difference between a first set of the estimates of the work of breathing values from a current predefined time window and a second set of the estimates of the work of breathing values from a previous predefined time window;
wherein the difference being higher than a predefined threshold is indicative of the patient reaching the sleep state.
4. The method of claim 1 , further comprising:
receiving an initial pressure level from a patient; and
delivering the initial pressure level to the patient while in a non-sleep state.
5. The method of claim 4 , wherein the pressure is increased to a prescription pressure level from the initial pressure level in response to the evaluation of the estimates of the work of breathing values indicating the patient reaching the sleep state.
6. The method of claim 4 , further comprising:
ramping pressure to the patient while in the non-sleep state from the initial pressure level to a prescription pressure level at a first predetermined rate;
wherein the pressure is increased to the prescription level at a second predetermined rate higher than the first predetermined rate in response to the evaluation of the estimates of the work of breathing values indicating the patient reaching the sleep state.
7. A method for delivering increased pressure levels to a patient undergoing CPAP therapy in response to detection of a sleep state based on an evaluation of patient work of breathing, the method comprising:
measuring, over a predefined time window encompassing one or more respiratory cycles, discrete samples of a control signal generated by a pressure controller to regulate delivered pressure at the patient;
generating a baseline control signal from a weighted average of the measured discrete samples of the control signal;
deriving a respiratory cycle period, an inspiration control time, and an expiration control time for each of the respiratory cycles within the predefined window;
deriving work of breathing values from the control signal for each of the inspiration control times and expiration control times, the work of breathing values being defined as the area between the control signal and the baseline control signal;
deriving mean and standard deviation values of the work of breathing values for each of the inspiration control times and expiration control times; and
increasing pressure to the patient in response to an assessment of the patient reaching the sleep state based upon at least one of the mean and standard deviation values of the work of breathing values for the inspiration control times and the expiration control times being higher than predefined threshold values.
8. The method of claim 7 , wherein:
the inspiration control time is defined as a first duration during which the measured discrete samples of the control signal exceed the baseline control signal; and
the expiration control time is defined as a second duration during which the measured discrete samples of the control signal are less than the baseline control signal.
9. The method of claim 7 , further comprising:
receiving an initial pressure level from a patient; and
delivering the initial pressure level to the patient while in a non-sleep state.
10. The method of claim 9 , wherein the pressure is increased to a prescription pressure level from the initial pressure level in response to the assessment of the patient reaching the sleep state.
11. The method of claim 9 , further comprising:
ramping pressure to the patient while in the non-sleep state from the initial pressure level to a prescription pressure level at a first predetermined rate;
wherein the pressure is increased to the prescription level at a second predetermined rate higher than the first predetermined rate in response to the assessment of the patient reaching the sleep state.
12. An article of manufacture comprising a non-transitory program storage medium readable by a data processor of a CPAP therapy device, the medium tangibly embodying one or more programs of instructions executable by the data processor to perform a method for continuous positive airway pressure (CPAP) therapy comprising:
measuring, over a predefined time window encompassing one or more respiratory cycles, discrete values of a control signal generated by a pressure controller to regulate delivered pressure at the patient;
generating a baseline control signal value from a weighted average of the measured discrete values of the control signal;
generating estimates of a respiratory cycle period, an inspiration control time, and an expiration control time, the inspiration control time being defined as a first duration during which the discrete values of the control signal exceed the baseline control signal, and the expiration control time being defined as a second duration during which the discrete values of the control signal are less than the baseline control signal;
generating estimates of one or more secondary control signal properties for each of the respective inspiration control time and expiration control time over at least one of the one or more respiratory cycles within the predefined time window, the one or more secondary control signal properties including work of breathing values derived from the control signal for the inspiration control time and the expiration control time respectively, the work of breathing values being defined as the area between the control signal and the baseline control signal; and
increasing pressure to the patient in response to an evaluation of the estimates of the work of breathing values indicative of the patient reaching a sleep state.