Tissue roll scaffolds

1. An apparatus for treating a wound having a cavity, the apparatus comprising:

a scaffold having a generally cylindrical shape, having a first end surface adapted to be inserted into the cavity of the wound and a second end surface adapted to receive reduced pressure from a pressure source to be provided to the wound, and comprising:

(i) a scaffold lamina being formed from a strip of material having surfaces extending between two edges, wherein the material includes a reticulated foam having a porous structure adapted to provide a structural matrix for the formation of tissue within the cavity of the wound and support protein adhesion, and

(ii) a tissue lamina being formed from a strip of material having surfaces extending between two edges, wherein the surfaces of the tissue lamina and the scaffold lamina are in fluid communication and rolled into the generally cylindrical shape of the scaffold, and wherein the edges of the tissue lamina and the scaffold lamina form the first and second end surfaces of the scaffold, respectively; and

a manifold adapted to be in fluid communication with the pressure source and the second end surface of the scaffold to provide reduced pressure to the scaffold lamina and the wound.

2. The apparatus of claim 1 , further comprising a drape formed of substantially impermeable material to cover the scaffold and the manifold within the wound to substantially maintain the reduced pressure within the wound when provided by the manifold.

3. The apparatus of claim 1 , wherein the manifold is positioned adjacent the second end surface of the scaffold.

4. The apparatus of claim 1 , wherein the manifold is in fluid communication with an end portion of the scaffold lamina.

5. The apparatus of claim 1 , wherein the tissue lamina comprises adipose tissue.

6. The apparatus of claim 5 , wherein the adipose tissue is derived from lipoaspirate.

7. The apparatus of claim 1 , wherein the tissue lamina comprises allograft, autograft or xenograft tissue.

8. The apparatus of claim 1 , wherein the scaffold lamina is formed from a bioinert or bioabsorbable material.

9. The apparatus of claim 1 , wherein the scaffold lamina is formed from a foam or gel material.

10. The apparatus of claim 1 , wherein the scaffold lamina comprises a bioactive agent selected from the group consisting of an antibiotic, an antibody and a growth factor.

11. The apparatus of claim 10 , wherein the bioactive agent is a growth hormone (GH), a bone morphogenetic protein (BMP), transforming growth factor-α (TGF-α), a TGF-β, a fibroblast growth factor (FGF), granulocyte-colony stimulating factor (G-CSF), granulocyte/macrophage-colony stimulating factor (GM-CSF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor/scatter factor (HGF/SF), an interleukin, tumor necrosis factor-α (TNF-α) or nerve growth factor (NGF).

12. The apparatus of claim 8 , wherein the scaffold lamina comprises collagen.

13. The apparatus of claim 1 , wherein the manifold comprises a bioinert material.

14. The apparatus of claim 1 , wherein the manifold comprises a bioabsorbable material.

15. The apparatus of claim 1 , wherein the scaffold lamina comprises a high void fraction for cell growth and tissue formation.

16. The apparatus of claim 1 , wherein the scaffold lamina comprises a material configured to support cellular ingrowth.

17. The apparatus of claim 1 , wherein a thickness of the scaffold lamina is greater than a thickness of the tissue lamina.

18. A method for treating a wound having a cavity, the method comprising:

positioning a scaffold within the cavity of the wound to provide reduced pressure to the wound, the scaffold having a generally cylindrical shape, having a first end surface adapted to be inserted into the cavity of the wound and a second end surface adapted to receive reduced pressure from a pressure source to be provided to the wound, and comprising:

(i) a scaffold lamina being formed from a strip of material having surfaces extending between two edges, wherein the material includes a reticulated foam having a porous structure adapted to provide a structural matrix for the formation of tissue within the cavity of the wound and support protein adhesion, and

(ii) a tissue lamina being formed from a strip of material having surfaces extending between two edges, wherein the surfaces of the tissue lamina and the scaffold lamina are in fluid communication and rolled into the generally cylindrical shape of the scaffold, and wherein the edges of the tissue lamina and the scaffold lamina form the first and second end surfaces of the scaffold, respectively; and

positioning a manifold in fluid communication with the second end surface of the scaffold to provide reduced pressure to the scaffold lamina and the wound, thereby treating the wound having a cavity.

19. The method of claim 18 , further comprising the step of covering the scaffold and the manifold within the wound with a substantially impermeable material to substantially maintain the reduced pressure within the wound when provided by the manifold.

20. The method of claim 18 , further comprising positioning the manifold adjacent the second end surface of the scaffold.

21. The method of claim 18 , further comprising positioning the manifold in fluid communication with an end portion of the scaffold lamina.

22. The method of claim 18 , wherein the tissue lamina comprises adipose tissue.

23. The method of claim 22 , wherein the adipose tissue is derived from lipoaspirate.

24. The method of claim 18 , wherein the tissue lamina comprises allograft, autograft or xenograft tissue.

25. A method for bulking a tissue site, the method comprising:

positioning a scaffold within the tissue site to provide reduced pressure to the tissue site, the scaffold having a generally cylindrical shape having a first end surface adapted to be inserted into the tissue site and a second end surface adapted to receive reduced pressure from a pressure source to be provided to the tissue site, and comprising:

(i) a scaffold lamina being formed from a strip of material having surfaces extending between two edges, wherein the material includes a reticulated foam having a porous structure adapted to provide a structural matrix for the formation of tissue within the tissue site and support protein adhesion, and

(ii) a tissue lamina being formed from a strip of material having surfaces extending between two edges, wherein the surfaces of the tissue lamina and the scaffold lamina are in fluid communication and rolled into the generally cylindrical shape of the scaffold, and wherein the edges of the tissue lamina and the scaffold lamina form the first and second end surfaces of the scaffold, respectively; and

positioning a manifold in fluid communication with the second end surface of the scaffold to provide reduced pressure to the scaffold lamina and the tissue site, thereby bulking the tissue site.

26. The method of claim 25 , further comprising the step of covering the scaffold and the manifold within the wound with a substantially impermeable material to substantially maintain the reduced pressure within the tissue site when provided by the manifold.

27. The method of claim 25 , further comprising positioning the manifold adjacent the second end surface of the scaffold.

28. The method of claim 25 , further comprising positioning the manifold in fluid communication with an end portion of the scaffold lamina.

29. The method of claim 25 , wherein the tissue lamina comprises adipose tissue.

30. The method of claim 29 , wherein the adipose tissue is derived from lipoaspirate.

31. The method of claim 25 , wherein the tissue lamina comprises allograft, autograft or xenograft tissue.