IP Library Granted Patent US 10,576,302
Granted Patent B2
US 10,576,302 · App. 14/838,566 · Granted Mar 3, 2020

Method and apparatus for monitoring a radiation therapy of a patient

Inventors: David Grodzki (Erlangen, DE); Annemarie Hausotte (Erlangen, DE); Bjoern Heismann (Erlangen, DE); Arne Hengerer (Moehrendorf, DE); Mark-Aleksi Keller-Reichenbecher (Sandhausen, DE); Sebastian Schmidt (Weisendorf, DE)
Assignee: Siemens Aktiengesellschaft
A61N5/1071A61B5/055A61B5/4836A61N5/1039G01R33/5608A61N2005/1055A61N2005/1074G01R33/56509
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Quick Facts
Patent No.
US 10,576,302
App. No.
14/838,566
Granted
Mar 3, 2020
Kind
B2
Abstract

In a method and magnetic resonance (MR) apparatus for monitoring a radiation therapy of a patient, first MR image data are acquired with a quantitative magnetic resonance method before an irradiation of a target area of the patient, and second MR image data are acquired with the quantitative magnetic resonance method after the irradiation of the target area of the patient. The first MR image data and the second MR image data are compared, and output information is generated on the basis of a result of the comparison.

Claims (30)

1. A method for monitoring a radiation therapy administered to a patient, comprising:

operating a magnetic resonance (MR) scanner with a quantitative MR fingerprinting method to acquire first MR image data before irradiating a target area of the patient with therapeutic radiation, the acquisition of the first MR image data including an acquisition of a first MR signal waveform associated with tissue of the patient in said target area;

operating an irradiation apparatus to irradiate the target area of the patient with therapeutic radiation; operating the MR scanner with said quantitative MR fingerprinting method to acquire second MR image data after irradiating said target area of the patient with said therapeutic radiation, the acquisition of the second MR image data including an acquisition of a second MR signal waveform;

in a processor, comparing said first MR image data and said second MR image data to obtain a comparison result by performing a signal comparison of said second MR signal waveform with said first MR signal waveform; and

generating output information at an output of said processor dependent on said comparison result.

2. A method as claimed in claim 1 , wherein the act of comparing said first MR image data and said second MR image data to obtain the comparison result comprises calculating a difference between said first MR signal waveform and said second MR signal waveform.

3. A method as claimed in claim 1 comprising, before comparing said first MR image data and said second MR image data, transforming at least one of said first MR image data and second MR image data to compensate for respectively different support positions of the patient during acquisition of said first MR image data and acquisition of said second MR image data.

4. A method as claimed in claim 1 , wherein the act of comparing said second MR signal waveform with said first MR signal waveform comprises computing a correlation between said second MR signal waveform and said first MR signal waveform with a correlation analysis in said processor.

5. A method as claimed in claim 1 comprising acquiring said first MR image data and said second MR image data from a same examination area of the patient, said examination area being delimited by parallel excitation of nuclear spins therein so as to be adapted in shape to said target area.

6. A method as claimed in claim 1 comprising:

in said processor, calculating a first dose distribution of said therapeutic radiation before said irradiation of the patient;

calculating a second dose distribution of said therapeutic radiation after irradiation of the patient; and

comparing said first and second dose distributions with each other,

wherein the output information is generated at an output of said processor further based upon said comparison result of said first and second dose distributions.

7. A method as claimed in claim 1 comprising transferring said output information to a planning computer and, in said planning computer, establishing an irradiation plan for a further irradiation of a target area of the patient with therapeutic radiation using said output information.

8. A magnetic resonance (MR) apparatus comprising:

an irradiation apparatus configured to irradiate a target area of a patient with therapeutic radiation;

an MR scanner;

a control computer configured to operate said MR scanner with a quantitative MR fingerprinting method to acquire first MR image data before irradiating the target area of the patient with therapeutic radiation, the acquisition of the first MR image data including an acquisition of a first MR signal waveform associated with tissue of the patient in said target area;

said control computer being configured to operate said MR scanner with said quantitative MR fingerprinting method to acquire second MR image data after irradiating said target area of the patient with said therapeutic radiation, the acquisition of the second MR image data including an acquisition of a second MR signal waveform;

a processor configured to compare said first MR image data and said second MR image data to obtain a comparison result by performing a signal comparison of said second MR signal waveform with said first MR signal waveform; and

said processor being configured to generate output information at an output of said processor dependent on said comparison result.

9. An apparatus for planning irradiation of a target area of a patient with therapeutic radiation, comprising:

an irradiation apparatus configured to irradiate a target area of a patient with therapeutic radiation;

a magnetic resonance (MR) scanner;

control computer configured to operate said magnetic resonance (MR) scanner with a quantitative MR fingerprinting method to acquire first MR image data before irradiating the target area of the patient with therapeutic radiation, the acquisition of the first MR image data including an acquisition of a first MR signal waveform associated with tissue of the patient in said target area;

said control computer configured to operate said MR scanner with said quantitative MR fingerprinting method to acquire second MR image data after irradiating said target area of the patient with said therapeutic radiation, the acquisition of the second MR image data including an acquisition of a second MR signal waveform;

a processor configured to compare said first MR image data and said second MR image data to obtain a comparison result by performing a signal comparison of said second MR signal waveform with said first MR signal waveform;

said processor being configured to generate output information at an output of said processor dependent on said comparison result; and

a planning computer in communication with said processor, said planning computer provided with said output information and configured to establish a parameter setting for further irradiation of a target area of the patient with therapeutic radiation based on said output information.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE PREVIOUSLY RECORDED AT REEL: 066088 FRAME: 0256. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jan 17, 2024
From: SIEMENS HEALTHCARE GMBH
To: SIEMENS HEALTHINEERS AG
Reel/Frame 071178/0246 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2023
From: SIEMENS HEALTHCARE GMBH
To: SIEMENS HEALTHINEERS AG
Reel/Frame 066088/0256 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2020
From: SIEMENS AKTIENGESELLSCHAFT
To: SIEMENS HEALTHCARE GMBH
Reel/Frame 052648/0591 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 9, 2016
From: GRODZKI, DAVID; HAUSOTTE, ANNEMARIE; HEISMANN, BJOERN; HENGERER, ARNE; KELLER-REICHENBECHER, MARK-ALEKSI; SCHMIDT, SEBASTIAN
To: SIEMENS AKTIENGESELLSCHAFT
Reel/Frame 037691/0528 →