Method for inducing angiogenesis
Disclosed herewith is a method for inducing angiogenesis using modified placental tissue or an extract thereof to treat conditions other than cardiovascular conditions.
1. A method for inducing angiogenesis in a non-cardiovascular body region of a subject having diabetic peripheral neuropathy, said method comprising delivering an effective amount of a composition comprising modified placental tissue to said non-cardiovascular body region, wherein said modified placental tissue comprises an amnion layer having an epithelial layer which has not been substantially removed.
2. The method of claim 1 , wherein blood flow to the non-cardiovascular body region is restricted.
3. The method of claim 1 , wherein the non-cardiovascular body region includes peripheral portions of the body, liver, lung, nerve, bone, or skin.
4. The method of claim 3 , wherein the peripheral portions of the body are limbs, hands, or feet.
5. The method of claim 1 , wherein the modified placental tissue further comprises one or more of isolated chorion, intermediate layer, Wharton's jelly, isolated amniotic epithelial layer, or any combination thereof.
6. The method of claim 1 , wherein the modified placental tissue is a tissue graft.
7. The method of claim 1 , wherein the modified placental tissue is micronized.
8. The method of claim 1 , wherein the composition is injectable.
9. The method of claim 1 , wherein the composition is a liquid, gel, or paste.
10. The method of claim 1 , wherein the composition is administered by a nebulizer.
11. A method for inducing angiogenesis in a non-cardiovascular body region of a subject having diabetic peripheral neuropathy, which method comprises injecting an effective amount of an aqueous solution comprising micronized modified placental tissue to said non-cardiovascular body region and maintaining said region under conditions wherein angiogenesis is induced, wherein said modified placental tissue comprises an amnion layer having an epithelial layer which has not been substantially removed.
12. The method of claim 11 , wherein the non-cardiovascular body region includes peripheral portions of the body, liver, lung, nerve, bone, or skin.