Peroxide Contact Lens Care Solution

1 . A method of cleaning and disinfecting a contact lens, the method comprising instructing a consumer to disinfect their contact lens comprising the following steps:

remove a contact from an eye and position the lens in a lens assembly that includes a cap member;

add a disinfection solution to a lens case such that the lens is submerged in the solution upon closure of the lens case with the cap member, said disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound, wherein the solution exhibits a pseudo first-order, half-life of hydrogen peroxide from 12 minutes to 30 minutes over an initial sixty minutes of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal.

2 . The method of claim 1 wherein upon closure of the lens case with the cap member the disinfection solution exhibits a pseudo first-order, half-life of hydrogen peroxide over the initial sixty minutes of from 14 minutes to 22 minutes, and the concentration of hydrogen peroxide after six hours of neutralization is less than 150 ppm.

3 . A method of cleaning and disinfecting a contact lens, the method comprising instructing a consumer to disinfect their contact lens comprising the following steps:

remove a contact from an eye and position the lens in a lens assembly that includes a cap member;

add a disinfection solution to a lens case such that the lens is submerged in the solution upon closure of the lens case with the cap member, said disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound, wherein upon closure of the lens case the solution exhibits a pseudo first-order, half-life of hydrogen peroxide over an initial sixty minutes of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal, said neutralization is 1.25 times to 2 times greater with the P-metal modulating compound in the solution than in the absence of the P-metal modulating compound.

4 . A method of cleaning and disinfecting a contact lens, the method comprising instructing a consumer to disinfect their contact lens comprising the following steps:

remove a contact from an eye and position the lens in a lens assembly that includes a cap member;

add a disinfection solution to a lens case such that the lens is submerged in the solution upon closure of the lens case with the cap member, said disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound, wherein the disinfection solution exhibits a hydrogen peroxide neutralization profile that is more effective against Candida albicans or Serratia marcescens by 0.5 log-kill or greater after an initial four hours of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal than an equivalent contact lens disinfection solution but without the P-metal modulating compound, said disinfection solution having an osmolality value of from 150 mOsmol/kg to 500 mOsmol/kg following neutralization of the hydrogen peroxide.

5 . The method of claim 1 wherein the P-metal modulating compound is of general formula I

wherein R 1 is C 1 -C 6 alkyl, —(CH 2 ) n CH( + NH 3 )(CO 2 − ) and n is 1 or 2, or NHR 3 ; and R 3 is H or R 2 , and R 2 is H, OH or C 1 -C 6 alkyl.

6 . The method of claim 1 wherein the P-metal modulating compound comprises one or two nitrogen atoms and one to six carbon atoms.

7 . The method of claim 1 wherein the molar ratio of the hydrogen peroxide to the P-metal modulating compound is from 3:1 to 100:1.

8 . The method of claim 3 wherein the P-metal modulating compound is of general formula I

wherein R 1 is C 1 -C 6 alkyl, —(CH 2 ) n CH( + NH 3 )(CO 2 − ) and n is 1 or 2, or NHR 3 ; and R 3 is H or R 2 , and R 2 is H, OH or C 1 -C 6 alkyl.

9 . The method of claim 3 wherein the P-metal modulating compound comprises one or two nitrogen atoms and one to six carbon atoms.

10 . The method of claim 4 wherein the P-metal modulating compound is of general formula I

wherein R 1 is C 1 -C 6 alkyl, —(CH 2 ) n CH( + NH 3 )(CO 2 − ) and n is 1 or 2, or NHR 3 ; and R 3 is H or R 2 , and R 2 is H, OH or C 1 -C 6 alkyl.

11 . The method of claim 4 wherein the P-metal modulating compound comprises one or two nitrogen atoms and one to six carbon atoms.

12 . The method of claim 1 wherein the P-metal modulating compound is an amino acid or a compound derived from an amino acid.

13 . The method of claim 12 wherein the amino acid is present in the solution from 0.05 wt. % to 0.4 wt. %.

14 . The method of claim 1 wherein the disinfection solution further comprises a low foam surfactant, particularly a polyoxyethylene/polyoxypropylene condensation polymer selected from the group consisting of Pluronic® L42, Pluronic® L43, Pluronic® L61, Pluronic® L81, Pluronic® 31R1, Pluronic® 31R2, Pluronic® 25R1, Pluronic® 1781, Pluronic® 17R2, Pluronic® 12R3 and Pluronic® 17R4.

15 . The method of claim 3 wherein the disinfection solution further comprises a low foam surfactant, particularly a polyoxyethylene/polyoxypropylene condensation polymer selected from the group consisting of Pluronic® L42, Pluronic® L43, Pluronic® L61, Pluronic® L81, Pluronic® 31R1, Pluronic® 31R2, Pluronic® 25R1, Pluronic® 17R1, Pluronic® 17R2, Pluronic® 12R3 and Pluronic® 17R4.

16 . The method of claim 4 wherein the disinfection solution further comprises a low foam surfactant, particularly a polyoxyethylene/polyoxypropylene condensation polymer selected from the group consisting of Pluronic® L42, Pluronic® L43, Pluronic® L61, Pluronic® L81, Pluronic® 31R1, Pluronic® 31R2, Pluronic® 25R1, Pluronic® 17R1, Pluronic® 17R2, Pluronic® 12R3 and Pluronic® 17R4.