Micronized placental tissue compositions and methods of making and using the same
Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
1. A method for treating inflammation in a subject, said method comprising administering a composition comprising micronized placental tissue particles to the site of said inflammation; said micronized placental tissue particles comprising an amnion layer and a chorion layer; wherein the chorion layer is layered directly over the amnion layer; and wherein an intermediate layer of said amnion layer has been substantially removed.
2. The method of claim 1 , wherein the amnion layer has an epithelial layer.
3. The method of claim 1 , wherein the amnion layer has an exposed basement membrane.
4. The method of claim 1 , wherein said micronized placental tissue particles further comprise one or more additional layers selected from the group consisting of amnion, chorion, intermediate tissue layer, allograft pericardium, allograft acellular dermis, Wharton's jelly, purified xenograft Type-I collagen, biocellulose polymers or copolymers, biocompatible synthetic polymer or copolymer films, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, and any combination thereof.
5. The method of claim 1 , wherein the micronized placental tissue particles are dehydrated.
6. The method of claim 1 , wherein the micronized placental tissue particles are less than 500 μm.
7. The method of claim 1 , wherein the micronized placental tissue particles are from 150 μm to 350 μm.
8. The method of claim 1 , wherein the micronized placental tissue particles are from 25 μm to 150 μm.
9. The method of claim 1 , wherein the micronized placental tissue particles are from 25 μm to 75 μm.
10. The method of claim 1 , wherein the inflammation is in a joint.
11. A method for treating an injury in or around a joint of a subject, said method comprising administering a composition comprising micronized placental tissue particles to the site of said injury; said micronized placental tissue particles comprising an amnion layer and a chorion layer; wherein the chorion layer is layered directly over the amnion layer; and wherein an intermediate layer of said amnion layer has been substantially removed.
12. The method of claim 11 , wherein the amnion layer has an epithelial layer.
13. The method of claim 11 , wherein the amnion layer has an exposed basement membrane.
14. The method of claim 11 , wherein said micronized placental tissue particles further comprise one or more additional layers selected from the group consisting of amnion, chorion, intermediate tissue layer, allograft pericardium, allograft acellular dermis, Wharton's jelly, purified xenograft Type-I collagen, biocellulose polymers or copolymers, biocompatible synthetic polymer or copolymer films, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, and any combination thereof.
15. The method of claim 11 , wherein the micronized placental tissue particles are dehydrated.
16. The method of claim 11 , wherein the micronized placental tissue particles are less than 500 μm.
17. The method of claim 11 , wherein the micronized placental tissue particles are from 150 μm to 350 μm.
18. The method of claim 11 , wherein the micronized placental tissue particles are from 25 μm to 150 μm.
19. The method of claim 11 , wherein the micronized placental tissue particles are from 25 μm to 75 μm.
20. The method of claim 11 , wherein the injury is caused by inflammation.