Carbamoyl phenylalaninol compounds and uses thereof
The present invention relates to carbamoyl phenylalaninol compounds and methods of using the same to treat disorders.
1. A method of treating excessive daytime sleepiness or fatigue, in a subject in need thereof, comprising administering to the subject a compound of Formula I:
wherein
R is optionally substituted lower alkyl of 1 to 8 carbon atoms, halogen, optionally substituted alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, cyano, trifluoromethyl, or optionally substituted thioalkoxy containing 1 to 3 carbon atoms;
x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
R 1 , R 2 , and R 3 are independently hydrogen, optionally substituted lower alkyl of 1 to 8 carbon atoms, optionally substituted aryl, optionally substituted arylalkyl, or optionally substituted cycloalkyl of 3 to 7 carbon atoms; or
R 2 and R 3 can he joined to form a 5 to 7-membered heterocycle optionally substituted with a member selected from the group consisting of alkyl and aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;
or a pharmaceuticallly acceptable salt thereof.
2. A method of treating nightmares and/or sleep-related disturbances associated with PTSD in a subject in need thereof, comprising administering to the subject a compound of Formula I:
wherein
R is optionally substituted lower alkyl of 1 to 8 carbon atoms, halogen, optionally substituted alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, cyano, trifluoromethyl, or optionally substituted thioaikoxy containing 1 to 3 carbon atoms;
x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
R 1 , R 2 , and R 3 are independently hydrogen, optionally substituted lower alkyl of 1 to 8 carbon atoms, optionally substituted aryl, optionally substituted arylalkyl, or optionally substituted cycloalkyl of 3 to 7 carbon atoms; or
R 2 and R 3 can he joined to form a 5 to 7-membered heterocycle. optionally substituted with a member selected from the group consisting of alkyl and aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;
or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein the compound is a compound of Formula II;
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein the compound is compound 1:
or a pharmaceutically acceptable salt thereof.
5. The method of claim 1 , wherein the compound is compound 2:
or a pharmaceutically acceptable salt thereof.
6. The method of claim 1 , comprising administering a composition comprising the compound.
7. The method of claim 1 , comprising administering a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
8. The method of claim 7 , wherein the composition is a dosage form.
9. The method of claim 8 , wherein the composition is an immediate release oral dosage form.
10. The method of claim 9 , wherein the composition is a tablet or a capsule.
11. The method of claim 1 , wherein the subject has excessive daytime sleepiness.
12. The method of claim 1 , wherein the subject has fatigue.
13. The method of claim 2 , wherein the compound is a compound of Formula II:
or a pharmaceutically acceptable salt thereof.
14. The method of claim 2 , wherein the compound is compound I:
or a pharmaceutically acceptable salt thereof.
15. The method of claim 2 , wherein the compound is compound 2:
or a pharmaceutically acceptable salt thereof.
16. The method of claim 2 , comprising administering a composition comprising the compound.
17. The method of claim 2 , comprising administering a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
18. The method of claim 17 , wherein the composition is a dosage form.
19. The method of claim 18 , wherein the composition is an immediate release oral dosage form.
20. The method of claim 19 , wherein the composition is a tablet or a capsule.