Carbamoyl phenylalaninol analogs and uses thereof

1. A compound of Formula V:

or a pharmaceutically acceptable salt thereof, wherein:

Z is S;

Y is C═S or SO 2 ;

R is optionally substituted C 1-8 alkyl, halogen, optionally substituted C 1-4 alkoxy, cyano, hydroxy, optionally substituted trifluoromethyl, or C 1-4 thioalkoxy;

n is 0, 1, 2, or 3, with the proviso that R may be the same or different when n is 2 or 3; and

R 1 and R 2 can be the same or different and are independently selected from the group consisting of hydrogen, optionally substituted C 1-8 alkyl, optionally substituted amide, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, and optionally substituted C 3-7 cycloalkyl;

or R 1 and R 2 can be joined to form a 5 to 7-membered heterocycle optionally substituted with alkyl or aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

2. The compound of claim 1 , having Formula Va:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , having Formula VIa:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , which is the hydrochloride salt.

5. A composition comprising the compound of claim 1 .

6. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.

7. The composition of claim 6 , wherein the composition is a dosage form.

8. The composition of claim 7 , wherein the composition is an immediate release oral dosage form.

9. The composition of claim 8 , wherein the composition is a tablet or a capsule.

10. A kit comprising the compound of claim 1 .

11. The compound of claim 1 , wherein R 1 and R 2 are hydrogen.

12. The compound of claim 1 , wherein n is 0.