IP Library › Granted Patent US 12,433,971
Granted Patent B2
US 12,433,971 · App. 16/823,616 · Granted Oct 7, 2025

Collagen reinforced tissue grafts

Inventor: Thomas J. Koob (Marietta, GA)
Assignee: MiMedx Group, Inc.
A61L15/40A61L15/325A61L27/24A61L27/3604A61L27/3645A61L27/3675A61L27/54A61L31/044A61L2430/32A61L2430/40
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Quick Facts
Patent No.
US 12,433,971
App. No.
16/823,616
Granted
Oct 7, 2025
Kind
B2
Abstract

This invention is directed to a multi-layered tissue graft comprising a collagen layer and at least one separated and washed placental tissue component and/or umbilical cord component, wherein the collagen is human collagen substantially free of non-human antigens.

Claims (19)

1. A micronized composition comprising prepared by micronizing a multi-layered tissue graft, said multi-layered tissue graft comprising a collagen layer and at least one separated and washed placental tissue component and/or umbilical cord component, wherein the collagen layer is reconstituted, pepsin-cleaved human placental collagen substantially free of non-human antigens; and wherein the collagen layer is 10 to 80 wt % of the multi-layered tissue graft.

2. The micronized composition of claim 1 , said multi-layered tissue graft comprising a collagen layer interposed between a first and a second layer of separated and washed placental tissue component and/or umbilical cord component.

3. The micronized composition of claim 2 , wherein the placental tissue component derives from at least one amnion layer.

4. The micronized composition of claim 2 , wherein the placental tissue component derives from at least one chorion layer.

5. The micronized composition of claim 2 , wherein the umbilical cord component comprises Wharton's jelly.

6. The micronized composition of claim 3 , wherein the at least one amnion layer comprises an epithelial side and a fibroblast side, and neither side has been substantially decellularized.

7. The micronized composition of claim 3 , wherein the at least one amnion layer comprises an epithelial side and a fibroblast side, and the epithelial side has been substantially decellularized.

8. The micronized composition of claim 3 , wherein the at least one amnion layer comprises an epithelial side and a fibroblast side, and the fibroblast side has been substantially decellularized.

9. The micronized composition of claim 3 , wherein the at least one amnion layer comprises an epithelial side and a fibroblast side, and both sides have been substantially decellularized.

10. The micronized composition of claim 1 , wherein the human collagen is isolated from one or more placental tissue components.

11. The micronized composition of claim 1 , wherein the collagen layer is 10 to 50 wt. % relative to the total weight of the tissue graft.

12. The micronized composition of claim 1 , wherein the layers are laminated together.

13. The micronized composition of claim 1 , wherein the collagen is crosslinked.

14. The micronized composition of claim 1 , wherein the tissue graft has been dehydrated to have a water content of less than 20 wt. % and micronized into particles having a size of less than about 100 μm.

15. The micronized composition of claim 1 , further comprising a pharmaceutically acceptable excipient.

16. A method for treating a subject comprising contacting the subject with the micronized composition of claim 1 .

17. The method of claim 16 , wherein the method comprises injecting into the subject the micronized composition.

18. The micronized composition of claim 1 , wherein the collagen layer is 30 to 80 wt. % of the tissue graft.

19. The micronized composition of claim 1 , wherein the collagen layer is 50 to 80 wt. % of the tissue graft.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S NAME FROM MIMDEX GROUP, INC. TO MIMEDX GROUP, INC. PREVIOUSLY RECORDED ON REEL 52180 FRAME 317. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF ASSIGNORS INTEREST. Recorded Sep 12, 2025
From: KOOB, THOMAS J.
To: MIMEDX GROUP, INC.
Reel/Frame 072888/0659 →
SECURITY INTEREST Recorded Jan 25, 2024
From: MIMEDX GROUP, INC.
To: CITIZENS BANK, N.A.
Reel/Frame 066371/0136 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 20, 2020
From: KOOB, THOMAS J.
To: MIMDEX GROUP, INC.
Reel/Frame 052180/0317 →
Continuity (3)
Division 14838305 · Aug 27, 2015
Provisional Application 62043300 · Aug 28, 2014
Related Publication 20200215221A1 · Jul 9, 2020
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