IP Library Granted Patent US 12,036,558
Granted Patent B2
US 12,036,558 · App. 16/963,428 · Granted Jul 16, 2024

Temperature adjustment stage

Inventors: Koji Miyazaki (Hino, JP); Hideyuki Fujii (Yoshikawa, JP); Ko Osawa (Hino, JP); Takanori Murayama (Tachikawa, JP)
Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
B01L7/00G01N21/03G01N21/41G01N31/22
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Quick Facts
Patent No.
US 12,036,558
App. No.
16/963,428
Granted
Jul 16, 2024
Kind
B2
Abstract

To provide a temperature adjustment stage that can efficiently heat a cartridge in accordance with necessity of heating each well. A temperature adjustment stage for heating a cartridge in which a plurality of wells that store a liquid are formed. The cartridge is used in an inspection system that detects an object captured by an immunoreaction, the wells include a labeled antibody well that stores a labeled antibody that labels the object, and there is provided a structure that does not heat the labeled antibody well.

Claims (26)

1. A system comprising:

a cartridge in which a plurality of wells that store a liquid are formed; and

a temperature adjustment stage for heating the cartridge, wherein

the cartridge is used in an inspection system that detects an object captured by an immunoreaction,

the plurality of the wells include a labeled antibody well that stores a labeled antibody that labels the object, and a cleaning liquid well,

the temperature adjustment stage is configured to adjust a temperature of the labeled antibody well lower than a temperature of the cleaning liquid well,

the temperature adjustment stage comprises a mounting recess in which the cartridge is mounted, and

the mounting recess is provided with an assisting part having a shape corresponding to a shape of a bottom part of the cleaning liquid well at a position corresponding to a position of the cleaning liquid well when the cartridge is mounted in the mounting recess.

2. The system according to claim 1 , wherein

the plurality of the wells further include at least one of a mixed diluent well, a specimen dilution well, or a measurement reagent well, and

the temperature adjustment stage is configured to heat at least one of the cleaning liquid well, the mixed diluent well, the specimen dilution well, or the measurement reagent well.

3. The system according to claim 2 , wherein the mounting recess is formed with a recess that prevents a bottom part of the labeled antibody well from coming into contact with the temperature adjustment stage when the cartridge is mounted in the mounting recess, and at least one of the bottom part of the cleaning liquid well, a bottom part of the mixed diluent well, a bottom part of the specimen dilution well, or a bottom part of the measurement reagent well contacts with the temperature adjustment stage.

4. The system according to claim 2 , wherein the mounting recess is disposed on a first surface of the temperature adjustment stage, the temperature adjustment stage further comprises:

a heater disposed on a second surface of the temperature adjustment stage, the first and second surfaces being opposite to each other, and the heater is not disposed at a position corresponding to a position of the labeled antibody well when the cartridge is mounted in the mounting recess, but is disposed at a position corresponding to a position of at least one of the cleaning liquid well, the mixed diluent well, the specimen dilution well, or the measurement reagent well.

5. The system according to claim 3 , wherein

the cartridge includes: a flow path chip having a flow path and a reaction field in the flow path, wherein the immunoreaction is performed in the reaction field; and an optical measurement chip having a prism that reflects light at a position including the reaction field, and

the mounting recess includes at least one of an abutting surface that abuts with a bottom surface of the optical measurement chip, or a wall part that contacts with a side surface of the optical measurement chip.

6. The system according to claim 3 , wherein the temperature adjustment stage further comprises: a wall formed around the mounting recess, and a part of the wall is cut out from an inner surface to an outer surface of the wall.

7. The system according to claim 4 , wherein

the cartridge includes: a flow path chip having a flow path and a reaction field in the flow path, wherein the immunoreaction is performed in the reaction field; and an optical measurement chip having a prism that reflects light at a position including the reaction field, and

the mounting recess includes at least one of an abutting surface that abuts with a bottom surface of the optical measurement chip, or a wall part that contacts with a side surface of the optical measurement chip.

8. The system according to claim 4 , wherein the temperature adjustment stage further comprises: a wall formed around the mounting recess, and a part of the wall is cut out from an inner surface to an outer surface of the wall.

9. The system according to claim 1 , wherein the cartridge includes: a flow path chip having a flow path and a reaction field in the flow path, wherein the immunoreaction is performed in the reaction field; and an optical measurement chip having a prism that reflects light at a position including the reaction field, and the mounting recess includes at least one of an abutting surface that abuts with a bottom surface of the optical measurement chip, or a wall part that contacts with a side surface of the optical measurement chip.

10. The system according to claim 1 , wherein the temperature adjustment stage further comprises: a wall formed around the mounting recess, and a part of the wall is cut out from an inner surface to an outer surface of the wall.

11. The system according to claim 5 , wherein the temperature adjustment stage further comprises: a wall formed around the mounting recess, and a part of the wall is cut out from an inner surface to an outer surface of the wall.

12. The system according to claim 1 , wherein when the cartridge is mounted in the mounting recess, a contact area where the cleaning liquid well comes into contact with the mounting recess is greater than a contact area where the labeled antibody well comes into contact with the mounting recess.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 21, 2022
From: KONICA MINOLTA, INC.
To: OTSUKA PHARMACEUTICAL CO., LTD.
Reel/Frame 059747/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2020
From: MIYAZAKI, KOJI; FUJII, HIDEYUKI; OSAWA, KO; MURAYAMA, TAKANORI
To: KONICA MINOLTA, INC.
Reel/Frame 053259/0343 →
Priority Claims (1)
JP 2018-012570 · Jan 29, 2018 · national
Continuity (1)
Related Publication 20210069716A1 · Mar 11, 2021