HPK1 antagonists and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
12. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
16. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
17. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
18. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
19. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
20. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
21. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
22. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
23. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
24. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
25. The compound of claim 1 , wherein said compound is
or a pharmaceutically acceptable salt thereof.
26. A pharmaceutical composition comprising a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
27. The pharmaceutical composition of claim 26 , wherein said compound is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
28. The pharmaceutical composition of claim 26 , wherein said compound is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
29. The pharmaceutical composition of claim 26 , wherein said compound is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.
30. The pharmaceutical composition of claim 12 , wherein said compound is selected from the group consisting of
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant, or vehicle.