Granted Patent B2

US 12,390,488 · App. 17/419,527 · Granted Aug 19, 2025

Inventors: Hannah C. Cohen (St. Paul, MN); Katie F. Wlaschin (St. Paul, MN); Yizhong Wang (Woodbury, MN); Amanda C. Engler (Woodbury, MN); Jie Yang (Woodbury, MN); Tiffany T. Ton (Woodbury, MN); Joel D. Oxman (Minneapolis, MN)

Assignee: Solventum Intellectual Properties Company

A61K33/00A61K8/25A61K8/922

Abstract

Claims (32)

1. An article comprising:

an oil phase comprising:

one or more plant-based oil present in an amount from 75 wt-% to 99 wt-%;

fumed silica present in an amount from 0.5 wt-% to 10 wt-%; and

an aqueous phase comprising:

water,

wherein the one or more plant-based oil is a solid at 25° C.,

wherein the article is solid set and homogenous at 25° C. without requiring emulsifiers,

wherein the article is characterized by a homogeneity that is stable upon heating to 45° C. and subsequently cooling to 25° C., and

wherein each wt-% is with respect to the weight of the article.

2. The article according to claim 1 , wherein the one or more plant-based oil is a hydrogenated vegetable oil.

3. The article according to claim 1 , wherein the one or more plant-based oil is present in an amount from 75 wt-% to 85 wt-% with respect to the weight of the article.

4. The article according to claim 1 , wherein the fumed silica is present in an amount from 4 wt-% to 8.5 wt-% with respect to the weight of the article.

5. The article according to claim 1 , wherein the water is present in an amount from 0.5 wt-% to 10 wt-% with respect to the weight of the article.

6. The article according to claim 1 , further comprising sweeteners, mineral salts, buffering components, flavorants, preservative agents, humectants, or a combination thereof.

7. The article according to claim 1 , further comprising aloe vera, folic acid, hyaluronic acid, ceramides, glycine, arginine, betaines, oxygenated glycerol triesters, vitamin E, vitamin B12, EDTA, cetyl pyridinium chloride, chlorhexidine, antiseptics, or a combination thereof.

8. The article according to claim 1 , wherein the article is characterized by a homogeneity that is stable upon heating to 80° C. and subsequently cooling to 25° C.

9. The article according to claim 1 , wherein the article prevents, inhibits, and/or disrupts the formation or maintenance of a biofilm in an area contacted with the article.

10. The article according to claim 1 , wherein the article reduces hydration loss in an area contacted by the article.

11. The article according to claim 1 , wherein the article increases lubricity or lubriciousness of an area contacted by the article.

12. A method of one or more of preventing, inhibiting, and disrupting the formation or maintenance of a biofilm in an oral tissue, the method comprising:

contacting an oral tissue with an article according to claim 1 .

13. A method of reducing hydration loss in an oral tissue, the method comprising:

contacting an oral tissue with an article according to claim 1 .

14. A method of increasing lubricity or lubriciousness in an oral tissue, the method comprising:

contacting an oral tissue with an article according to claim 1 .

15. A method of reducing the effects of xerostomia, dry mouth, or both, the method comprising:

contacting an oral tissue with an article according to claim 1 .

16. The article of claim 1 , further comprising a sweetener and one or more mineral salt.

17. The article of claim 1 , further comprising xylitol.

18. The article of claim 1 , further comprising a calcium salt, a magnesium salt, a phosphate salt, or a combination thereof.

19. The article of claim 1 , further comprising xylitol and one or more of a calcium salt, a magnesium salt, and a phosphate salt.

Assignments (2)

Continuity (2)

References Cited (122)