Non-invasive neural interface
A neuromodulator includes an electromagnetic (EM) wave generator configured to generate EM waves remote from a patient and to direct the EM waves to one or more target regions within the patient. Frequencies of the EM waves fall outside a range of frequencies that activates neurons. Intersection of the EM waves in each target region creates envelope-modulated electric and magnetic fields having one or more frequencies that fall within the range of frequencies that activates neurons. The neuromodulator includes control circuitry configured to control parameters of the EM waves produced by the EM wave generator. The neuromodulator may use feedback based on one or more of patient input and/or sensing of physiological signals in order to close the loop and control the EM waves.
1. A system, comprising:
a neuromodulator comprising:
an electromagnetic (EM) wave generator configured to generate EM waves remote from a patient and to direct the EM waves to one or more target regions within the patient, frequencies of the EM waves exceeding a range of frequencies that activates neurons, intersection of the EM waves in each target region creating envelope-modulated electric and magnetic fields having one or more frequencies that fall within the range of frequencies that activates neurons;
a receiver configured to receive a signal responsive to the neuron activation; and
control circuitry configured to control parameters of the EM waves produced by the EM wave generator in response to the received signal.
2. The system of claim 1 , wherein the receiver is configured to receive a physiologic signal responsive to the neuron activation.
3. The system of claim 2 , wherein the physiologic signal comprises one or more of heart rate (HR), blood pressure (BP), respiratory rate (RR), and body temperature.
4. The system of claim 1 , wherein the receiver is configured to receive a neural activity signal sensed from the target region.
5. The system of claim 1 , wherein the receiver is configured to receive a neural activity signal sensed from a second target region different than the target region.
6. The system of claim 1 , wherein the frequencies of the EM waves are greater than about 150 kHz and frequencies of the envelope-modulated electric and magnetic fields are less than about 100 kHz.
7. The system of claim 1 , wherein the control circuitry is configured to control the parameters of the EM waves to change one or more characteristics of the envelope-modulated electrical and magnetic fields in the target regions.
8. The system of claim 7 , wherein:
the parameters that change the characteristics of the envelope-modulated electrical and magnetic fields include frequency, phase, and amplitude; and
the one or more characteristics of the envelope-modulated electrical and magnetic fields include frequency, amplitude, and modulation depth.
9. The system of claim 1 , wherein:
the EM wave generator comprises a phased array configured to generate multiple EM waves; and
the control circuitry is configured to control one or more parameters of the multiple EM waves such that the multiple EM waves undergo constructive and destructive interference that one or both of focuses and steers the multiple EM waves to the target regions.
10. The system of claim 1 , wherein an amplitude of the envelope modulated electric field:
exceeds a threshold for neural activation; or
is below a threshold for activation of neurons within the target region.
11. The system of claim 1 , further comprising communications circuitry configured to transfer patient information from an additional device to the neuromodulation device; and
wherein the control circuitry is configured to modify one or more parameters of the EM waves based on the patient information.
12. The system of claim 11 , wherein the patient information comprises sensed physiological signals.
13. The system of claim 11 , wherein the patient information is based on patient-provided input.
14. A method, comprising:
generating electromagnetic (EM) waves at a location remote from a patient, frequencies of the EM waves exceeding a range of frequencies that activate neurons;
directing the EM waves to one or more target regions within the patient;
intersecting the EM waves in the target regions, in each target region, intersection of the EM waves creating envelope-modulated electrical and magnetic fields having frequencies falling within the range of frequencies that activate neurons;
receiving a signal responsive to the neuron activation; and
controlling parameters of the generated EM waves in response to the received signal.
15. The method of claim 14 , wherein the received signal is a physiologic signal responsive to the neuron activation.
16. The method of claim 15 , wherein the physiologic signal comprises one or more of heart rate (HR), blood pressure (BP), respiratory rate (RR), and body temperature.
17. The method of claim 14 , wherein the received signal is a neural activity signal sensed from the target region.
18. The method of claim 14 wherein the received signal is a neural activity signal sensed from a second target region different than the target region.
19. The method of claim 14 , further comprising controlling one or more parameters of the first and second EM waves to change one or more characteristics of the envelope-modulated electrical and magnetic fields in the target regions.
20. The method of claim 14 , wherein the frequencies of the EM waves are greater than about 150 kHz and frequencies of the envelope-modulated electric and magnetic fields are less than about 100 kHz.