IP Library Granted Patent US 11,715,179
Granted Patent B2
US 11,715,179 · App. 17/504,725 · Granted Aug 1, 2023

Systems and methods for improving magnetic resonance imaging using deep learning

Inventors: Tao Zhang (Mountain View, CA); Enhao Gong (Sunnyvale, CA)
Assignee: Subtle Medical, Inc.
G06T5/002A61B5/055A61B5/7267G01R33/561G01R33/565G01R33/5608G01R33/56545G06T5/001G06T2200/24G06T2207/10088G06T2207/20004G06T2207/20081G06T2207/20084G06T2207/30168
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Quick Facts
Patent No.
US 11,715,179
App. No.
17/504,725
Granted
Aug 1, 2023
Kind
B2
Abstract

A computer-implemented method is provided for improving image quality with shortened acquisition time. The method comprises: determining an accelerated image acquisition scheme for imaging a subject using a medical imaging apparatus; acquiring a medical image of the subject according to the accelerated image acquisition scheme using the medical imaging apparatus; applying a deep network model to the medical image to improve the quality of the medical image; and outputting an improved quality image of the subject, for analysis by a physician.

Claims (23)

1. A computer-implemented method for improving image quality with shortened acquisition time, the method comprising:

(a) acquiring a first medical image having a first image quality, wherein the first medical image is a magnetic resonance (MR) medical image of a subject;

(b) applying a deep network model to the first medical image to generate a second medical image, wherein the deep learning model is a deep residual learning model, wherein the second medical image has a second image quality, wherein the second image quality is higher than the first image quality, and wherein the second image quality has greater signal-to-noise ratio (SNR), higher resolution, or less aliasing compared with the first image quality; and

wherein the deep network model is trained by adaptively tuning one or more model parameters to approximate a reference image.

2. The computer-implemented method of claim 1 , wherein the deep learning model is trained using training datasets comprising at least a pair of low quality image and the reference image.

3. The computer-implemented method of claim 2 , wherein the low quality image is generated by applying one or more filters or adding synthetic noise to the reference image to create noise or undersampling artifacts.

4. The computer-implemented method of claim 2 , wherein the low quality image is acquired using an imaging apparatus with shortened acquisition time, undersampled k-space or reduced number of repetitions.

5. The computer-implemented method of claim 2 , wherein signal-to-noise ratio (SNR) or resolution of the reference image is higher than that of the low quality image.

6. The computer-implemented method of claim 2 , wherein the training datasets comprise patches of the pair of low quality image and the reference image.

7. The computer-implemented method of claim 6 , wherein the patches are selected based on one or more metrics quantifying an image similarity.

8. The computer-implemented method of claim 1 , wherein the first medical image is acquired with a shortened acquisition time.

9. The computer-implemented method of claim 1 , wherein the first medical image comprises undersampled k-space image or image acquired using reduced number of repetitions.

10. A non-transitory computer-readable storage medium including instructions that, when executed by one or more processors, cause the one or more processors to perform operations comprising:

(a) acquiring a first medical image having a first image quality, wherein the first medical image is a magnetic resonance (MR) medical image of a subject;

(b) applying a deep network model to the first medical image to generate a second medical image, wherein the deep learning model is a deep residual learning model, wherein the second medical image has a second image quality, wherein the second image quality is higher than the first image quality, and wherein the second image quality has greater signal-to-noise ratio (SNR), higher resolution, or less aliasing compared with the first image quality;

and

wherein the deep network model is trained by adaptively tuning one or more model parameters to approximate a reference image.

11. The non-transitory computer-readable storage medium of claim 10 , wherein the deep learning model is trained using training datasets comprising at least a pair of low quality image and the reference image.

12. The non-transitory computer-readable storage medium of claim 11 , wherein the low quality image is generated by applying one or more filters or adding synthetic noise to the reference image to create noise or undersampling artifacts.

13. The non-transitory computer-readable storage medium of claim 11 , wherein the low quality image is acquired using an imaging apparatus with shortened acquisition time, undersampled k-space or reduced number of repetitions.

14. The non-transitory computer-readable storage medium of claim 11 , wherein signal-to-noise ratio (SNR) or resolution of the reference image is higher than that of the low quality image.

15. The non-transitory computer-readable storage medium of claim 11 , wherein the training datasets comprise patches of the pair of low quality image and the reference image.

16. The non-transitory computer-readable storage medium of claim 11 , wherein the first medical image comprises undersampled k-space image, image acquired using reduced number of repetitions, or image acquired with shortened acquisition time.

Assignments (2)
GRANT OF SECURITY INTEREST IN PATENTS Recorded May 29, 2026
From: SUBTLE MEDICAL, INC.
To: MS PRIVATE CREDIT ADMINISTRATIVE SERVICES LLC
Reel/Frame 075648/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2021
From: ZHANG, TAO; GONG, ENHAO
To: SUBTLE MEDICAL, INC.
Reel/Frame 058143/0575 →
Continuity (4)
Continuation 17069036 · Oct 13, 2020
Continuation PCTUS2019027826 · Apr 17, 2019
Provisional Application 62659837 · Apr 19, 2018
Related Publication 20220130017A1 · Apr 28, 2022
Cited By (1)
US 12,569,198