LUBRICIOUS COATINGS FOR MEDICAL DEVICES WITH ENHANCED DURABILITY
Embodiments herein relate to lubricious coatings for medical devices. A coated medical device is included having a substrate and a lubricious coating disposed thereon. In some embodiments, the lubricious coating can include an outer protective layer including long polymer chains. The long polymer chains can include a bonded end and a mobile free end. In some embodiments, the lubricious coating can include a hydrogel layer and long polymer chains that are at least partially disposed within the lubricious coating. Other embodiments are also included herein.
1 . A coated medical device comprising:
a substrate; and
a lubricious coating, the lubricious coating comprising
an outer protective layer, the outer protective layer comprising long polymer chains, wherein the long polymer chains include a bonded end and a mobile free end; and
wherein the lubricious coating is disposed on the substrate.
2 . The coated medical device of claim 1 , wherein the long polymer chains have an average chain length greater than 100 kDa.
3 . The coated medical device of claim 1 , wherein the long polymer chains have an average chain length from 100 to 300 kDa.
4 - 5 . (canceled)
6 . The coated medical device of claim 1 , the long polymer chains comprising at least one selected from the group consisting of a comb structure, a bottle brush structure, a star structure, a hyperbranched structure, a mucin structure, and a dendritic structure.
7 . The coated medical device of claim 1 , wherein the long polymer chains are uncross-linked.
8 . The coated medical device of claim 1 , the lubricious coating further comprising an underlying hydrogel layer.
9 . The coated medical device of claim 8 , the hydrogel layer comprising one or more of polyvinylpyrrolidone (PVP), a photo-reactive PVP, polyacrylamide (PA), and a photo-reactive PA.
10 . The coated medical device of claim 8 , wherein the outer protective layer exhibits a coefficient of friction less than the hydrogel layer.
11 . The coated medical device of claim 8 , the hydrogel layer comprising:
a first sublayer; and
a second sublayer.
12 . The coated medical device of claim 11 , wherein the second sublayer is crosslinked to a greater extent than the first sublayer.
13 . The coated medical device of claim 8 , the lubricious coating further comprising a base coat.
14 - 16 . (canceled)
17 . The coated medical device of claim 1 , the long polymer chains comprising at least one selected from the group consisting of a polyvinylpyrrolidone, a polyvinylalcohol, a polyacrylamide, a polyethyleneglycol, a polysulfobetaine, a phosphoryl choline capped polymer, and a poloxamer.
18 . The coated medical device of claim 1 , the long polymer chains comprising a polyzwitterion.
19 . The coated medical device of claim 1 , the long polymer chains comprising a zwitterionic subunit, wherein the zwitterionic subunit disposed on an exterior portion of the long polymer chains.
20 . The coated medical device of claim 1 , the long polymer chains comprising a zwitterionic subunit, wherein the zwitterionic subunit is disposed on an end of the long polymer chains.
21 . The coated medical device of claim 1 , the long polymer chains comprising a non-ionic backbone chain.
22 . The coated medical device of claim 1 , wherein the long polymer chains are grafted onto an underlying surface or at least partially embedded within and crosslinked into an underlying layer.
23 - 24 . (canceled)
25 . The coated medical device of claim 1 , the outer protective layer further comprising non-covalently bonded long polymer chains, wherein the non-covalently bonded long polymer chains are configured to elute from the lubricious coating.
26 . The coated medical device of claim 1 , wherein the long polymer chains include a covalently bonded end and a mobile free end.
27 - 32 . (canceled)
33 . A coated medical device comprising:
a substrate; and
a lubricious coating, the lubricious coating comprising
a hydrogel layer; and
long polymer chains, wherein the long polymer chains are disposed at least partially within the lubricious coating.
34 - 136 . (canceled)