IP Library Granted Patent US 12,596,164
Granted Patent B2
US 12,596,164 · App. 18/524,229 · Granted Apr 7, 2026

Method and system for improving image contrast in fast driven equilibrium inversion recovery imaging

Inventors: Constantin von Deuster (Zürich, CH); Daniel Nanz (Hombrechtikon, CH)
Assignees: Siemens Healthineers AG; Balgrist Campus AG
G01R33/5615
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,596,164
App. No.
18/524,229
Granted
Apr 7, 2026
Kind
B2
Abstract

A method and a magnetic resonance imaging (MRI) system improve an MRI signal from a magnetization of interest. The method includes performing an MRI pulse sequence containing three consecutive radio frequency (RF) elements, namely, a first element that is an inversion-recovery pulse sequence characterized by a time of inversion, a second element that is an image-encoding pulse sequence starting at the time of inversion with an excitation RF pulse followed by an image-encoding gradient and a data sampling. The second element is followed by a third element. An MRI signal generated by the object and sampled by image readout blocks applied to the object by the MRI system during each repetition time, is acquired. From the MRI signal, an image of the object is reconstructed. The third element is a modified driven-equilibrium (mDE) pulse sequence configured for achieving a conversion of a transverse magnetization component.

Claims (15)

1 . A magnetic resonance imaging (MRI) method for improving an MRI signal generated by a magnetization of interest when imaging an object placed in an examination volume of an MRI system, the method comprises the steps of:

performing, by the MRI system, an MRI pulse sequence containing three consecutive radio frequency (RF) elements, namely, a first element being an inversion-recovery pulse sequence characterized by a time of inversion), a second element being an image-encoding pulse sequence starting at the time of inversion with an excitation RF pulse followed by at least one image-encoding gradient and at least one data sampling, the second element being followed by a third element, the third element being a modified driven-equilibrium (hereafter “mDE”) pulse sequence configured for achieving a conversion of a transverse magnetization component of the magnetization of interest into positive longitudinal magnetization, aligned with positive z-axis and B0-field direction;

acquiring, by the MRI system, an MRI signal generated by the object and sampled by image readout blocks applied to the object by the MRI system during each repetition time; and

reconstructing, from the MRI signal, an image of the object.

2 . The MRI method according to claim 1 , wherein the mDE pulse sequence ends by a phase shifted flip-back pulse characterized by a +90 degree flip angle.

3 . The MRI method according to claim 1 , wherein the first element is a STIR pulse sequence.

4 . The MRI method according to claim 1 , wherein the second element contains a single or multiple data samplings.

5 . The MRI method according to claim 1 , wherein the second element is a sequence configured for generating at least one multiple gradient or spin echo.

6 . The MRI method according to claim 1 , wherein the second element is a sequence configured for generating a combination of gradient and spin echoes.

7 . The MRI method according to claim 1 , wherein the second element is a turbo-spin-echo-based pulse sequence.

8 . A magnetic resonance imaging (MRI) system, comprising:

a processor configured for carrying out the MRI method according to claim 1 .

9 . The MRI method according to claim 2 , wherein the phase shifted flip-back pulse is characterized by a 90° phase shift relative to a refocusing RF pulse, or non phase shifted relative to the excitation RF pulse, or 180° phase shift relative to a flip-back pulse of a driven-equilibrium pulse sequence.

10 . The MRI method according to claim 2 , wherein the mDE pulse sequence contains a first RF pulse temporally located in a middle of a time period separating a time at which the +90° phase shifted flip-back pulse is applied and a last time at which a magnetization was refocused.

11 . The MRI method according to claim 2 , wherein the mDE pulse sequence contains a first RF pulse that is a 180-degree RF pulse applied at a time equal to half an echo spacing after a last echo signal of an echo train, and the +90° flip-back pulse is applied at a time equal to half the echo spacing after the first 180-degree RF pulse.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NUMBER PREVIOUSLY RECORDED ON REEL 66974 FRAME 534. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Apr 3, 2024
From: SIEMENS HEALTHINEERS INTERNATIONAL AG
To: SIEMENS HEALTHINEERS AG
Reel/Frame 066990/0847 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2024
From: SIEMENS HEALTHINEERS INTERNATIONAL AG
To: SIEMENS HEALTHINEERS AG
Reel/Frame 066974/0534 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2023
From: SIEMENS HEALTHCARE GMBH
To: SIEMENS HEALTHINEERS AG
Reel/Frame 066267/0346 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2023
From: VON DEUSTER, CONSTANTIN
To: SIEMENS HEALTHINEERS INTERNATIONAL AG
Reel/Frame 065905/0334 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2023
From: NANZ, DANIEL
To: BALGRIST CAMPUS AG
Reel/Frame 065905/0374 →
Priority Claims (1)
EP 22216530 · Dec 23, 2022 · regional
Continuity (1)
Related Publication 20240210507A1 · Jun 27, 2024
References Cited (25)
US 5248942A · Ratzel et al. · 1993 [cited by applicant]
US 6456071B1 · Hennig · 2002 [cited by examiner]
US 20150164368A1 · Werden · 2015 [cited by applicant]
US 20180081016A1 · Carinci et al. · 2018 [cited by applicant]
US 20210199741A1 · Amemiya et al. · 2021 [cited by applicant]
US 20210199742A1 · Lyu et al. · 2021 [cited by applicant]
CN 101401723A · 2009 [cited by examiner]
CN 105259198A · 2016 [cited by applicant]
CN 108363026A · 2018 [cited by applicant]
EP 1273922A1 · 2003 [cited by examiner]
EP 3336570A1 · 2018 [cited by examiner]
JP H11253417A · 1999 [cited by examiner]
JP 2004166751A · 2004 [cited by applicant]
JP 2021104198A · 2021 [cited by applicant]
WO WO2019241459A1 · 2019 [cited by examiner]
Melhem, Elias R. et al; “Cervical spine: three-dimensional fast spin-echo MR imaging-improved recovery of longitudinal magnetization with driven equilibrium pulse”; Radiology; vol. 218; No. 1; Date: Jan. 1, 2001; pp. 28… [cited by applicant]
Bydder, G. M. et al:“MRI: Use of the inversion recovery pulse sequence”; Clinical Radiology, Elsevier; Amsterdam; NL; vol. 53; No. Date Mar. 1, 1998; pp. 159-176; XP005426183; ISSN: 0009-9260;DOI:10.1016/S0009-9260(98)8… [cited by applicant]
Bydder, G.M. et al:“MR imaging: clinical use of the inversion recovery sequence”; J Comput Assist Tomogr; vol. 9; No. 4; Date: Jul. 1, 1985; pp. 659-675; XP093050879. [cited by applicant]
Pravatä, E., et al., Dedicated 3D-T2-STIR-ZOOMit Imaging Improves Demyelinating Lesion Detection in the Anterior Visual Pathways of Patients with Multiple Sclerosis. American Journal of Neuroradiology, 2021. 42(6): p. 1… [cited by applicant]
Becker, E.D., et al., Driven Equilibrium Fourier Transform Spectroscopy. A New Method for Nuclear Magnetic Resonance Signal Enhancement. Journal of the American Chemical Society, 1969. 91 (27): p. 7784-7785. [cited by applicant]
Waugh, J.S., Sensitivity in Fourier transform NMR spectroscopy of slowly relaxing systems. Journal of Molecular Spectroscopy, 1970. 35(2): p. 298-305. [cited by applicant]
Waldstein, P. et al . . . , Driven Equilibrium Methods for Enhancement of Nuclear Transients. Review of Scientific Instruments, 1971. 42(4): p. 437-440. [cited by applicant]
Wallace, W.E., Theory and Optimization of the Pulsed NMR Driven Equilibrium Technique. The Journal of Chemical, Physics, 1971. 54(3): p. 1425-1427. [cited by applicant]
Jones, D.E., Fourier transform nuclear magnetic resonance. II. Driven equilibrium fourier transform and spin-echo fourier transform. Journal of Magnetic Resonance (1969), 1972. 6(2): p. 183-190. [cited by applicant]
Van Uijen, C.M.Jet al., Driven-equilibrium radiofrequency pulses in NMR imaging. Magnetic Resonance in Medicine, 1984. 1(4): p. 502-507. [cited by applicant]