HEAT TREATMENT MEANS FOR PRINTING DEVICE OF AN ENZYMATIC SYNTHESIS APPARATUS

1 . A printing device configured for the enzymatic synthesis of biomolecules, comprising

a print head,

at least one ink reservoir containing synthesis reagents, and

a substrate plate configured to receive ink drops,

wherein the printing device comprises at least one of a heater and a cooler configured to generate a temperature differential between the substrate plate and at least one of the print head and the ink reservoir,

wherein the temperature differential is at least 10° C., and wherein the temperature of the substrate plate is higher than the temperature of the at least one of the print head and the ink reservoir.

2 . The printing device of claim 1 , wherein the at least one of the heater and the cooler are configured so that a temperature measured at the at least one of the print head and the ink reservoir is between 0 and 25° C. and a temperature measured at the substrate plate is between 25 and 60° C.

3 . The printing device of claim 1 , wherein the printing device comprises the cooler, wherein the cooler is at the at least one of the print head and the ink tank.

4 . The printing device of claim 1 , wherein the printing device comprises the heater, wherein the heater is downstream of the print head.

5 . The printing device of claim 4 , wherein the printing device further comprises the cooler, wherein the cooler is arranged on at least one feed duct of the print head.

6 . The printing device of claim 4 , wherein the printing device further comprises the cooler, wherein the cooler is arranged on the ink tank.

7 . The printing device of claim 4 , wherein the printing device further comprises the cooler, wherein the cooler comprises a housing within which the at least one of the print head and the ink reservoir are arranged.

8 . The printing device of claim 5 , wherein the heater comprises a thermal block arranged in contact with the substrate plate.

9 . The printing device of claim 5 , wherein the heater comprises a system for infrared irradiation of the substrate plate.

10 . The printing device of claim 5 , wherein the heater comprises a circulation zone configured for the passage of a flow of heat transfer fluid, wherein the substrate plate is arranged to cover the circulation zone.

11 . The printing device of claim 5 , comprising a cover configured to cover the substrate plate, said cover comprising the heater.

12 . The printing device of claim 1 , wherein the printing device is configured for isolating the substrate plate.

13 . The printing device of claim 1 , wherein the printing device is configured for moistening the substrate plate.

14 . The printing device of claim 1 , comprising an enclosure configured to cover the substrate plate, wherein the enclosure comprises the heater and a temperature-humidity controller.

15 . The printing device of claim 14 , wherein the enclosure comprises at least one fan.

16 . A method for performing enzymatic synthesis of biomolecules with a printing device, wherein the printing device comprises an ink reservoir, a print head, and a substrate plate, the method comprising:

providing ink to the ink reservoir, wherein the ink comprises synthesis reagents,

generating a temperature differential between the substrate plate and at least one of the ink reservoir and the print head, wherein the temperature differential is at least 10° C., and wherein a first temperature measured at the at least one of the ink reservoir and the print head is between 0 and 25° C., and a second temperature measured at the substrate plate is between 25° C. and 60° C.,

generating a plurality of ink droplets at the print head, wherein the print head is connected to the ink reservoir, and

depositing the plurality of ink droplets onto the substrate plate.