Patent Assignment
Reel/Frame 025126/0241
Security Agreement
Recorded: 2010-10-12
Pages: 36
Assignor
EXAGEN DIAGNOSTICS, INC.
Executed: 2010-10-12
Assignee
CYPRESS BIOSCIENCE, INC.
4350 EXECUTIVE DRIVE, SUITE 325, SAN DIEGO, CALIFORNIA, 92121
Covered Properties
(57)
Diagnosis and Monitoring of Systemic Lupus Erythematosus and of Scleroderma
PCT:
PCT/US2002/028910 ↗
Methods of Quantifying Methotrexate Metabolites
PCT:
PCT/US2003/027313 ↗
Method for Direct Detection of Individual Methotrexate Metabolities
PCT:
PCT/US2004/006312 ↗
Identification and Monitoring of Systemic Lupus Erythematosus
PCT:
PCT/US2004/011982 ↗
Monitoring Immunologic, Hematologic and Inflammatory Diseases
PCT:
PCT/US2004/018552 ↗
Methods for Optimizing Clinical Responsiveness to Methotrexate Therapy Using Metabolite Profiling and Pharmacogenetics
PCT:
PCT/US2004/027851 ↗
Real Time Method of Detecting Acute Inflammatory Conditions
PCT:
PCT/US2005/011914 ↗
Diagnosing and Monitoring Inflammatory Diseases by Measuring Complement Components on White Blood Cells
PCT:
PCT/US2005/016436 ↗
Methods for Predicting Methotrexate Polyglutamate Levels Using Pharmacogenetics
PCT:
PCT/US2005/020957 ↗
Methods of Predicting Methotrexate Efficacy and Toxicity
PCT:
PCT/US2006/016246 ↗
Methods and Compositions for Improved Diagnostic Assays
PCT:
PCT/US2008/076302 ↗
Prediction of an Individual's Risk of Developing Rheumatoid Arthritis
PCT:
PCT/US2009/041443 ↗
Method for Diagnosis and Monitoring of Disease Activity and Response to Treatment in Systemic Lupus Erythematosus (Sle) and Other Autoimmune Diseases
PCT:
PCT/US2009/061085 ↗
Methods of Quantifying Methotrexate Metabolites
Methods for Direct Detection of Individual Methotrexate Metabolites
Methotrexate compliance packaging
Application:
10/384,353 →
Publication:
US 2004/0176381
Diagnosis and Monitoring of Systemic Lupus Erythematosus and of Scleroderma
Diagnosing and Monitoring Inflammatory Diseases by Measuring Complement Components on White Blood Cells
Identification and Monitoring of Systemic Lupus Erythematosus
Monitoring Immunologic, Hematologic and Inflammatory Diseases
Methods for Optimizing Clinical Responsiveness to Methotrexate Therapy Using Metabolite Profiling and Pharmacogenetics
Real Time Method of Detecting Acute Inflammatory Conditions
Methods for Predicting Methotrexate Polyglutamate Levels Using Pharmacogenetics
Methods of Predicting Methotrexate Efficacy and Toxicity
Application:
11/380,171 →
Publication:
US 2006/0286571
Genetic Markers for Prognosis of Antifolate Treatment Efficacy
Methotrexate Compliance Packaging
Application:
11/555,216 →
Publication:
US 2007/0093497
Compositions Comprising Bisphosphonate and an Antifolate
Application:
11/670,674 →
Publication:
US 2007/0225258
Systems and Methods for Predicting an Individual's Risk of Developing Rheumatoid Arthritis
Pharmacogenetic Method for Prediction of the Efficacy of Methotrexate Monotherapy in Recent-Onset Arthritis
Genetic Markers for Prognosis of Antifolate Treatment Efficacy
Methods for Optimizing Clinical Responsiveness to Methotrexate Therapy Using Metabolite Profiling and Pharmacogenetics
Application:
12/191,286 →
Publication:
US 2009/0197266
Methods for Optimizing Clinical Responsiveness to Methotrexate Therapy Using Metabolite Profiling and Pharmacogenetics
Application:
12/191,287 →
Publication:
US 2009/0197267
Methods of Predicting Methotrexate Efficacy and Toxicity
Application:
12/194,501 →
Publication:
US 2010/0203507
Methods of Predicting Methotrexate Efficacy and Toxicity
Application:
12/194,503 →
Publication:
US 2010/0203508
Prediction of an Individual's Risk of Developing Rheumatoid Arthritis
Application:
12/428,299 →
Publication:
US 2009/0265116
Diagnosing and Monitoring Inflammatory Diseases by Measuring Complement Components on White Blood Cells
Application:
12/511,956 →
Publication:
US 2009/0298198
Identification and Monitoring of Systemic Lupus Erythematosus
Method for Diagnosis and Monitoring of Disease Activity and Response to Treatment in Systemic Lupus Erythematosus (Sle) and Other Autoimmune Diseases
Application:
12/581,057 →
Publication:
US 2010/0233752
Methods for Predicting Methotrexate Polyglutamate Levels Using Pharmacogenetics
Application:
12/698,966 →
Publication:
US 2010/0203539
Methods and Compositions for Improved Diagnostic Assays
Application:
12/748,060 →
Publication:
US 2011/0189777
Genetic Markers for Prognosis of Antifolate Treatment Efficacy
Application:
12/748,838 →
Publication:
US 2010/0240541
Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma
Application:
60/318,541 →
Monitoring immunologic, hematologic, and inflammatory diseases
Application:
60/478,493 →
Real time method of detecting acute inflammatory conditions
Application:
60/560,986 →
Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
Application:
60/570,406 →
Real time method of detecting acute inflammatory conditions
Application:
60/579,621 →
Methods for predicting methotrexate polyglutamate levels using pharmacogenetics
Application:
60/580,141 →
Methods for evaluating risk associated with methotrexate therapy using pharmacogenetics
Application:
60/676,442 →
Methods for monitoring methotrexate therapy using pharmacogenomic and metabolite biomarkers
Application:
60/731,598 →
Systems and methods for predicting an individual's risk of developing rheumatoid arthritus
Application:
60/790,531 →
Pharmacogenetic method for prediction of the efficacy of methotrexate monotherapy in recent-onset arthritis
Application:
60/840,973 →
Methods for calibration of diagnostic instrumentation
Application:
60/995,712 →
Buffer compositions for diagnostic assays
Application:
60/995,714 →
Compositions for use as diagnostic assay controls and methods for producing same
Application:
60/995,716 →
Prediction of an Individual's Risk of Developing Rheumatoid Arthritis
Application:
61/047,094 →
Method for Diagnosis and Monitoring of Disease Activity and Response to Treatment in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases
Application:
61/105,865 →
Cell-Based Complement Activation Product Algorithm for Diagnosing Systemic Lupus Erythematosus
Application:
61/252,626 →
Related Assignments
(25)
Other recorded transfers of the patents in this record — the chain of ownership.
Assignment of Assignor's Interest
Jun 9, 2003
From: WALSH, MICHAEL J.
To: PROMETHEUS LABORATORIES, INC.
Reel/Frame 014158/0021 →
Assignment of Assignor's Interest
Jun 13, 2003
From: DERVIEUX, THIERRY; RICHERSON, RUSSELL B.
To: PROMETHEUS LABORATORIES, INC.
Reel/Frame 014243/0464 →
Assignment of Assignor's Interest
Oct 29, 2004
From: AHEARN, JOSEPH M.; MANZI, SUSAN M.
To: UNIVERSITY OF PITTSBURGH, A CORPORATION OF THE STATE OF PENNSYLVANIA
Reel/Frame 015317/0678 →
Assignment of Assignor's Interest
Jan 24, 2005
From: DERVIEUX, THIERRY; WALSH, MICHAEL
To: PROMETHEUS LABORATORIES INC.
Reel/Frame 015619/0081 →
Assignment of Assignor's Interest
Sep 15, 2005
From: AHEARN, JOSEPH M.; MANZI, SUSAN M.
To: UNIVERSITY OF PITTSBURGH
Reel/Frame 016543/0053 →
Notice of Grant of Security Interest
Sep 27, 2005
From: PROMETHEUS LABORATORIES INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 016580/0723 →
Assignment of Assignor's Interest
Dec 6, 2005
From: DERVIEUX, THIERRY
To: PROMETHEUS LABORATORIES INC.
Reel/Frame 017091/0574 →
Assignment of Assignor's Interest
Jul 26, 2006
From: GUCHELAAR, HENDRIK IAN; HUIZINGA, TOM WIHELM JOHANNES
To: ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC
Reel/Frame 018017/0001 →
Assignment of Assignor's Interest
Aug 22, 2006
From: AHEAM, JOSEPH M.; MANZI, SUSAN M.
To: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 018254/0710 →
Assignment of Assignor's Interest
Oct 12, 2006
From: AHEARN, JOSEPH M.; MANZI, SUSAN M.; LIU, CHAU-CHING
To: UNIVERSITY OF PITTSBURGH
Reel/Frame 018382/0374 →
Assignment of Assignor's Interest
Nov 20, 2006
From: NAVRATIL, JEANNINE
To: UNIVERSITY OF PITTSBURGH
Reel/Frame 018539/0928 →
Assignment of Assignor's Interest
May 18, 2007
From: WALSH, MICHAEL J.
To: PROMETHEUS LABORATORIES INC.
Reel/Frame 019316/0322 →
Assignment of Assignor's Interest
May 18, 2007
From: DERVIEUX, THIERRY
To: PROMETHEUS LABORATORIES INC.
Reel/Frame 019316/0315 →
Notice of Grant of Security Interest
Sep 28, 2007
From: PROMETHEUS LABORATORIES INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 019892/0404 →
Termination of Security Interest in Patents
Oct 8, 2007
From: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
To: PROMETHEUS LABORATORIES, INC.
Reel/Frame 019920/0883 →
Assignment of Assignor's Interest
Oct 31, 2007
From: WALSH, MICHAEL J.
To: PROPRIUS PHARMACEUTICALS, INC.
Reel/Frame 020048/0874 →
Assignment of Assignor's Interest
May 29, 2008
From: AHEARN, JOSEPH M.; MANZI, SUSAN M.
To: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 021013/0568 →
Confirmatory License
Aug 1, 2008
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 021326/0774 →
Assignment of Assignor's Interest
Nov 10, 2008
From: GRAZIANO, DANIEL F.; DONNENBERG, ALBERT D.
To: CELLATOPE CORPORATION
Reel/Frame 021809/0269 →
Assignment of Assignor's Interest
Dec 10, 2008
From: PROPRIUS PHARMACEUTICALS, INC.
To: CYPRESS BIOSCIENCE INC.
Reel/Frame 021958/0186 →
Assignment of Assignor's Interest
Feb 3, 2009
From: DERVIEUX, THIERRY; WALSH, MICHAEL
To: PROMETHEUS LABORATORIES INC.
Reel/Frame 022198/0911 →
Assignment of Assignor's Interest
Mar 18, 2009
From: CELLATOPE CORPORATION
To: CYPRESS BIOSCIENCE, INC.
Reel/Frame 022417/0384 →
Confirmatory License
Aug 13, 2009
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023094/0214 →
Confirmatory License
Oct 23, 2009
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023409/0633 →
Notice of Grant of Security Interest in Patents
Dec 22, 2009
From: PROMETHEUS LABORATORIES INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 023679/0428 →