Non-surgical, localized delivery of compositions for placental growth factors
Described herewith are compositions comprising placental growth factors and methods for non-surgical, localized delivery thereof. The composition is delivered to a diseased or injured organ and/or body part and is formulated in a manner which allows for localized retention of the composition at the site of delivery.
1. A composition comprising a sufficient amount of placental growth factors to treat a diseased or injured organ or body part wherein said composition is in the form of a localized mass when applied to or proximate to said diseased or injured organ or body part; wherein said composition is free of modified placental tissue particles; wherein said growth factors are extracted from modified placental tissue; and wherein said modified placental tissue comprises amnion substantially free of intermediate layer.
2. The composition of claim 1 , further comprising a localization agent.
3. The composition of claim 2 , wherein the localization agent is a thixotropic agent, or a phase changing agent.
4. The composition of claim 3 , wherein the thixotropic agent is selected from the group consisting of hyaluronic acid, collagen, thrombin gels, fibrin gels and fibrin glues.
5. The composition of claim 3 , wherein the phase changing agent is a gel forming agent.
6. The composition of claim 5 , wherein the gel forming agent is a copolymer or tripolymer of oxyethylene and oxypropylene units.
7. The composition of claim 2 , wherein the localization agent is selected from the group consisting of a hydrogel, a polymer, and a collagen gel.
8. The composition of claim 1 , wherein the composition forms a localized bioerodible mass when applied to or proximate to said diseased or injured organ or body part.
9. The composition of claim 1 , wherein said modified placental tissue further comprises chorion.
10. A method for preparing a composition for localized delivery of placental growth factors, comprising combining an aqueous solution of placental growth factors with a sufficient amount of a localization agent, whereby the composition is locally retained at the site of delivery upon administration; wherein said composition is free of modified placental tissue particles; wherein said growth factors are extracted from modified placental tissue; and wherein said modified placental tissue comprises amnion substantially free of intermediate layer.