IP Library › Granted Patent US 12,551,509
Granted Patent B2
US 12,551,509 · App. 16/043,520 · Granted Feb 17, 2026

Acellular regenerative products and methods of their manufacture

Inventors: Ryan Dregalla (Lyons, CO); Leonard R. Duford (Tampa, FL); Dean Nistal (Aurora, CO); Tracee Gruber (Denver, CO)
Assignee: Lucina Patent Holdco, LLC
A61K35/50A61L15/40A61L26/0095A61L27/3604A61L27/3616A61L27/3645A61L27/60A61K35/35A61K47/36A61K47/42A61L2300/414A61L2430/34
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Quick Facts
Patent No.
US 12,551,509
App. No.
16/043,520
Granted
Feb 17, 2026
Kind
B2
Abstract

An acellular product may be derived from human placenta and may be used in various scenarios for wound healing. Because the product may be acellular, the product may be processed for storage and transportation with minimal degradation. The product may include various scaffolding such as biomaterials or human tissue, and the scaffolding may be infused with various plasmas and agents. The cell-free treatment may maintain the biological activity of many therapeutic agents found within cells and may possess multiple structural components to support cellular attachment. The structural components or scaffolds may function as a reservoir of highly diffusible chemotactic and cellular-programming factors that may be useful to treat injury and disease.

Claims (12)

1 . A method of treating a wound in a human or animal, said method comprising:

applying an acellular placental product to the wound site, said acellular placental product comprising a human amniotic plasma portion and an intact intermediate layer scaffold membrane portion;

said intermediate layer being isolated from human amniotic membrane;

said intact intermediate layer scaffold membrane portion being impregnated with said human amniotic plasma portion.

2 . The method of claim 1 , said wound being a dermal wound.

3 . The method of claim 1 , said wound being an incision wound.

4 . The method of claim 1 , said wound being a surgical scar.

5 . The method of claim 1 said wound being a deep narrow wound.

6 . The method of claim 1 , wherein said plasma portion comprises extracellular matrix.

7 . The method of claim 1 , wherein said plasma portion comprises one or more adjuvant factors.

8 . The method of claim 7 , wherein said one or more adjuvant factors comprise at least one growth factor.

9 . The method of claim 1 , comprising substantially no fibrin or fibrinogen.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2020
From: LUCINA BIOSCIENCES, LLC
To: LUCINA PATENT HOLDCO, LLC
Reel/Frame 052907/0369 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2018
From: DREGALLA, RYAN; DUFORD, LEONARD R.; NISTAL, DEAN; GRUBER, TRACEE
To: LUCINA BIOSCIENCES, LLC
Reel/Frame 046454/0314 →
Continuity (3)
Continuation In Part 14945128 · Nov 18, 2015
Provisional Application 62668903 · May 9, 2018
Related Publication 20180325962A1 · Nov 15, 2018
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