IP Library › Granted Patent US 6,900,228
Granted Patent B1
US 6,900,228 · App. 09/623,872 · Granted May 31, 2005

Opiate compounds, methods of making and methods of use

Assignee: Research Triangle Institute
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Quick Facts
Patent No.
US 6,900,228
App. No.
09/623,872
Granted
May 31, 2005
Kind
B1
Abstract

The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.

Claims (7)

1. A compound represented by the formula:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , which is cis-substituted.

3. The compound of claim 1 , which is trans-substituted.

4. A method of binding opioid receptors, comprising administering an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof to a mammalian subject in need thereof.

5. The method of claim 4 , wherein delta opioid receptors are bound.

6. The method of claim 4 , wherein the compound functions as an agonist selective for the delta receptor.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 6, 2011
From: RESEARCH TRIANGLE INSTITUTE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 027330/0758 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2002
From: CARROLL, FRANK I.; THOMAS, JAMES B.; MASCARELLA, S. WAYNE
To: RESEARCH TRIANGLE INSTITUTE
Reel/Frame 012629/0454 →
Continuity (2)
Provisional Application 6010790200 · Nov 10, 1998
Provisional Application 6007740200 · Mar 10, 1998