Treatment of autoimmune conditions with copolymer 1 and related copolymers
View Patent ↗The present invention provides heteropolymer compositions and peptide compositions, and methods of making and using therapeutic compositions comprising amino acid heteropolymers for treatment of a subject for an autoimmune or an inflammatory disease, the heteropolymer compositions made by solid state synthesis. The invention also provides kits for assaying binding of a composition to a water-soluble MHC protein.
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an amount of a mixture of terpolymers, each terpolymer consisting of tyrosine, alanine and lysine.
2. The pharmaceutical composition of claim 1 , wherein said tyrosine is present in a mole fraction of about 0.005 to about 0.250; said alanine is present in a mole fraction of about 0.3 to about 0.6; and lysine is present in a mole fraction of about 0.1 to about 0.5.
3. The pharmaceutical composition of claim 1 , wherein said tyrosine is present in a mole fraction of 0.10, said alanine is present in a mole fraction of 0.54, and said lysine is present in a mole fraction of 0.35.
4. The pharmaceutical composition of claim 1 wherein said mixture of terpolymers has an average molecular weight of about 2,000 to about 40,000 daltons.
5. The pharmaceutical composition of claim 1 wherein said mixture of terpolymers has an average molecular weight of about 4,000 to about 9,000 daltons.