IP Library › Granted Patent US 7,030,289
Granted Patent B2
US 7,030,289 · App. 09/861,399 · Granted Apr 18, 2006

Stabilization of milk from transgenic animals

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Quick Facts
Patent No.
US 7,030,289
App. No.
09/861,399
Granted
Apr 18, 2006
Kind
B2
Abstract

The present invention relates to the stabilization of milk from transgenic animals. In particular, the invention relates to the protection of proteins (e.g. fibrinogen) expressed in milk from transgenic animals by co-expression of a serine proteinase inhibitor (e.g., α 1 -antitrypsin) in the milk of the transgenic animals.

Claims (2)

1. A method for stabilizing heterologous fibrinogen expressed in the milk of a transgenic non-human mammal comprising co-expressing, with said heterologous fibrinogen in the milk of said mammal, alpha-1-antitrypsin operably linked to a milk-protein specific promoter.

2. The method, as claimed in claim 1 , wherein the mammal is a sheep, cow, goat, rabbit, mouse, camel, water-buffalo, pig or horse.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Jan 28, 2020
From: ORBIMED ROYALTY OPPORTUNITIES II, LP
To: PHARMING GROUP N.V.; PHARMING TECHNOLOGIES B.V.; PHARMING INTELLECTUAL PROPERTY B.V.; BROEKMAN INSTITUUT B.V.; PHARMING B.V.; PHARMING AMERICAS B.V.; PHARMING HEALTHCARE, INC.
Reel/Frame 051722/0304 →
AMENDED AND RESTATED INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded May 16, 2017
From: PHARMING INTELLECTUAL PROPERTY B.V.
To: ORBIMED ROYALTY OPPORTUNITIES II, LP
Reel/Frame 042481/0139 →
SECURITY INTEREST Recorded Dec 7, 2016
From: PHARMING INTELLECTUAL PROPERTY B.V.
To: SILICON VALLEY BANK
Reel/Frame 040839/0865 →