Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties
View Patent ↗An article including a surface having a coating thereon, in which the coating includes a base coat, firmly adhered to the surface, and a hydrophilic, biocompatible top-coat. An antibiotic ceramic component is dispersed in one or both of the base coat and top-coat. Preferably, the ceramic component is dispersed in the base coat. In a preferred embodiment, the ceramic component is a zeolite with silver ions exchanged onto internal acidic sites of the zeolite, and the top-coat includes a polysaccharide, such as hyaluronan. The zeolite is highly effective in imparting anti-microbial character to the coating.
1. An article including a surface having a bilaminar, lubricious, and hydrophilic coat thereon, said coating comprising:
(a) a polysaccharide conponent; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component,
wherein the antibiotic ceramic component comprises a zeolite material.
2. An article including a surface having a bilaminar, lubricious, and hydrophilic coating thereon, said coating comprising:
(a) a polysaccharide component; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component,
wherein the polysaccharide component comprises hyaluronan.
3. An article including a surface having a bilaminar, lubricious, and hydrophilic coating thereon, said coating comprising:
(a) a polysaccharide component; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component,
the article comprising a tubing made from a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
4. An article including a surface having a bilaminar, lubricious, and hydrophilic coating thereon, said coating comprising:
(a) a polysaccharide component; and
(b) an antibiotic ceramic component dispersed within the polysaccharide component,
wherein the surface is formed of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
5. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
coating the object on a surface portion thereof with bilaminar, lubricious, and hydrophilic coating comprising:
(i) a polysaccharide component; and
(ii) an antibiotic ceramic component dispersed within the polysaccharide component,
wherein the polysaccharide component comprises hyaluronan.
6. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
coating the object on a surface portion thereof with bilaminar, lubricious, and hydrophilic coating comprising:
(i) a polysaccharide component; and
(ii) an antibiotic ceramic component dispersed within the polysaccharide component,
wherein the object comprises a tubing made of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
7. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
coating the object on a surface portion thereof with a bilaminar, lubricious, and hydrophilic coating comprising:
(i) a polysaccharide component; and
(ii) an antibiotic ceramic component dispersed within the polysaccharide component,
wherein the object comprises a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
8. An article comprising a coating, the coating being bilaminar, lubricious, and hydrophilic, the coating containing hyaluronan and a silver ion exchanged zeolite.
9. An article comprising a substrate having a bilaminar coating, the coating including a base coat and a top-coat containing hyaluronan, wherein the base coat contains silver ion exchanged zeolite, and wherein the top coat is lubricious and hydrophilic.
10. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:
coating the object on a surface portion thereof with a bilaminar, lubricious, and hydrophilic coating comprising:
(i) a base coat which adheres firmly to said surface portion, and
(ii) a hydrophilic, biocompatible top-coat, the top-coat being chemically grafted to said base coat, the top-coat including a polysaccharide component,
the method further comprising dispersing an antibiotic ceramic component within said base coat.
11. The method of claim 10 , wherein the antibiotic ceramic component comprises a zeolite component.
12. The method of claim 10 , wherein the zeolite component comprises silver ions ion-exchanged thereon.
13. The method of claim 10 , wherein the polysaccharide component comprises hyaluronan.
14. The method of claim 10 , wherein the object comprises polymeric tubing.
15. The method of claim 10 , wherein the object comprises polymeric catheter tubing.
16. The method of claim 10 , wherein the object comprises a tubing made of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
17. The method of claim 10 , wherein the object comprises a polymeric material.
18. The method of claim 10 , wherein the object comprises a material selected from the group consisting of ethyl vinyl acetate and polyurethane.
19. An article having a bilaminar, lubricious, and hydrophilic coating which includes a polysaccharide and silver ion exchanged zeolite.
20. An article having a bilaminar, lubricious, and hydrophilic coating which includes hyaluronan and a silver ion exchanged zeolite.