Molecular target of neurotoxicity
The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterization and/or treatment (or management) of neuro degenerative diseases, particularly amyotrophic lateral sclerosis.
1. A method for the treatment of Amyotropic Lateral Sclerosis, comprising administering to a subject in need thereof a compound selected from the group consisting of pentoxifylline and etazolate.
2. A method according to claim 1 , comprising administering to said subject an effective amount of pentoxifylline.
3. A method according to claim 1 , comprising administering to said subject an effective amount of etazolate.
4. The method of claim 1 wherein said treatment reduces neuronal excitotoxicity at the early stage of Amyotropic Lateral Sclerosis.
5. The method of claim 2 wherein said treatment reduces neuronal excitotoxicity at the early stage of Amyotropic Lateral Sclerosis.
6. The method of claim 3 wherein said treatment reduces neuronal excitotoxicity at the early stage of Amyotropic Lateral Sclerosis.
7. A method for reducing early neuronal excitotoxicity associated with Amyotrophic Lateral Sclerosis, comprising administering to a subject in need thereof an effective amount of a compound selected from the group consisting of pentoxifylline and etazolate.