IP Library Granted Patent US 7,816,560
Granted Patent B1
US 7,816,560 · App. 10/031,145 · Granted Oct 19, 2010

Long chain n-alkyl compounds and oxa-derivatives thereof

Assignees: Thomas Jefferson University; The Chancellor, Masters and Scholars of the University of Oxford; United Therapeutics Corporation
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Quick Facts
Patent No.
US 7,816,560
App. No.
10/031,145
Granted
Oct 19, 2010
Kind
B1
Abstract

Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C 8 -C 16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.

Claims (5)

1. A compound having the formula

wherein R 1 an oxa-substituted derivative of a C 8 -C 16 alkyl or a pharmaceutically acceptable salt or solvate of said compound.

2. The compound of claim 1 , wherein the compound is N-nonyl-1,5,6-trideoxy-1,5-imino-D-galactitol (N-nonyl MeDGJ), or a physiologically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound is N-(7-oxa-nonyl)-1,5,6-trideoxy-1,5-imino-D-galactitol (N-7-oxa-nonyl MeDGJ), or a physiologically acceptable salt thereof.

4. The compound of claim 1 , wherein R 1 is a C 8 -C 16 alkyl.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 23, 2015
From: UNITED THERAPEUTICS CORPORATION
To: UNITHER VIROLOGY, LLC
Reel/Frame 036869/0480 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 13, 2007
From: SYNERGY PHARMACEUTICALS INC.
To: UNITED THERAPEUTICS CORPORATION
Reel/Frame 020098/0696 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 3, 2002
From: PICKER, DONALD H.; JACOB, GARY S.
To: SYNERGY PHARMACEUTICALS, INC.
Reel/Frame 016075/0530 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 3, 2002
From: BLOCK, TIMOTHY M.; MEHTA, ANAND
To: THOMAS JEFFERSON UNIVERSITY
Reel/Frame 013732/0841 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 3, 2002
From: ZITZMANN, NICOLE; BUTTERS, TERRY D.; PLATT, FRANCES M.; CARROUEE, SANDRA; FLEET, GEORGE W.J.; DWEK, RAYMOND A.; DURANTEL, DAVID
To: THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Reel/Frame 013737/0932 →
Continuity (2)
Provisional Application 6014810100 · Aug 10, 1999
Provisional Application 6019862100 · Apr 20, 2000