Methods and apparatuses for drug delivery to an intravascular occlusion
A method for delivering a drug to the site of an intravascular occlusion. A guidewire having a balloon at one end is advanced across the occlusion using a guide catheter, and the balloon is inflated distal to the occlusion to occlude the blood vessel. An aspiration catheter is then inserted into the vessel with its tip less than about 5 mm from the surface of the balloon, and a drug is delivered which flows distal to proximal to treat the occlusion.
1. A method for treating an intravascular occlusion, comprising:
delivering a catheter having a proximal end and a distal end and a lumen extending therethrough into a blood vessel to a site near the intravascular occlusion, the catheter having an occlusive device on the distal end;
actuating the occlusive device at a location distal to the intravascular occlusion to at least partially occlude blood flow through the vessel; and
delivering a drug-containing fluid through the lumen of the catheter and out through at least one hole in a proximal face of the occlusive device such that the fluid is delivered in a distal to proximal direction.
2. The method of claim 1 , wherein the drug-containing fluid is delivered through a plurality of holes in the proximal face of the occlusive device.
3. The method of claim 1 , wherein the occlusive device is a balloon.
4. The method of claim 1 , wherein the drug-containing fluid is delivered at a flow rate of between about 0.1 to 3 cc/second.
5. A method for treating an intravascular occlusion, comprising:
delivering a catheter having a proximal end and a distal end and a lumen extending therethrough into a blood vessel to a site near the intravascular occlusion, the catheter having a balloon on the distal end;
inflating the balloon at a location distal to the intravascular occlusion to at least partially occlude blood flow through the vessel; and
delivering a drug-containing fluid through a plurality of holes in a proximal face of the balloon and across the intravascular occlusion in a distal to proximal direction, the drug being injected through the lumen of the catheter.
6. The method of claim 5 , wherein the drug-containing fluid delivered through the lumen is used to inflate the balloon.